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<p>The present study focused on the Au@TiO<sub>2</sub>-rGO nanocomposite, highlighting its dual functionality as a sonosensitizer for sonodynamic therapy (SDT) and as a dual-enzyme mimic for enhanced therapeutic efficacy. TiO<sub>2</sub>, a widely recognized sonosensitizer, is incorporated with gold nanoparticles (Au) and reduced graphene oxide (rGO) to create Au@TiO<sub>2</sub>-rGO. In this work, we have elaborated Au@TiO<sub>2</sub>-rGO nanocomposite using a simple solvothermal procedure using only a preferable solvent that acts as both reducing and surfactant molecules. This prevents and minimizes the formation of many byproducts which can inhibit the intrinsic properties of the nanocomposite. This nanocomposite displayed enhanced sonosensitizing efficacy and sonothermal effects, attributed to the synergistic effects of Au, TiO<sub>2</sub>, and rGO. Additionally, the nanocomposite exhibited dual enzyme-like mimicking activities, acting as a peroxidase-mimic under ultrasound activation for increased •OH radical production and a glucose oxidase-mimic for glucose depletion, contributing to a synergistic starving-like therapy. Comprehensive characterizations confirmed the nanocomposite’s structure, and experimental results demonstrate its superior sonosensitizing and enzyme-like activities compared to control nanocomposites. The findings highlighted the potential of Au@TiO<sub>2</sub>-rGO as a multifunctional nanocomposite for medical applications.</p>

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Enhanced Sonosensitizing and Dual-Enzyme Mimicking Activities of Au@TiO2-rGO Nanocomposite for Synergistic Medical Applications

  • 期刊论文

  • 发表日期：

    2025年1月28日

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  • Elaa Chiba,
  • Sami Ameur,
  • Ridha Ajjel,
  • Fadhel Aloulou,
  • Tariq Altalhi,
  • Amine Mezni

摘要

The present study focused on the Au@TiO2-rGO nanocomposite, highlighting its dual functionality as a sonosensitizer for sonodynamic therapy (SDT) and as a dual-enzyme mimic for enhanced therapeutic efficacy. TiO2, a widely recognized sonosensitizer, is incorporated with gold nanoparticles (Au) and reduced graphene oxide (rGO) to create Au@TiO2-rGO. In this work, we have elaborated Au@TiO2-rGO nanocomposite using a simple solvothermal procedure using only a preferable solvent that acts as both reducing and surfactant molecules. This prevents and minimizes the formation of many byproducts which can inhibit the intrinsic properties of the nanocomposite. This nanocomposite displayed enhanced sonosensitizing efficacy and sonothermal effects, attributed to the synergistic effects of Au, TiO2, and rGO. Additionally, the nanocomposite exhibited dual enzyme-like mimicking activities, acting as a peroxidase-mimic under ultrasound activation for increased •OH radical production and a glucose oxidase-mimic for glucose depletion, contributing to a synergistic starving-like therapy. Comprehensive characterizations confirmed the nanocomposite’s structure, and experimental results demonstrate its superior sonosensitizing and enzyme-like activities compared to control nanocomposites. The findings highlighted the potential of Au@TiO2-rGO as a multifunctional nanocomposite for medical applications.