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<p>In this study, liposomes were formulated using conventional soybean lecithin and hydrogenated soybean lecithin, combined with egg lecithin and cholesterol, all coated with polyethylene glycol (PEG) and loaded with vincristine. The liposomes exhibited an approximate size of 340&#xa0;nm for those made with soybean lecithin and 244&#xa0;nm for those using hydrogenated soybean lecithin. Their preparation was carried out through the lipid bilayer hydration method. To enhance the amount of encapsulated drug, vincristine was incorporated into a vitamin E (α-tocopherol) oil-in-water (O/W) emulsion. This approach aims to optimize the encapsulation efficiency of vincristine, prevent its degradation during the preparation process, and extend the drug's lifespan within the liposomes, thereby facilitating a controlled and sustained release at the target site, while also providing antioxidants as support in cancer therapy. Vitamin E is known for its instability, a challenge that can be mitigated by using α-tocopherol acetate, its esterified form. Thus, an emulsion-based delivery system may provide an alternative method for delivering lipid-soluble bioactive in combination with water-soluble compounds. Both formulations demonstrated an encapsulation efficiency exceeding 50%, with hydrogenated soybean lecithin showing greater stability and a higher quantity of encapsulated drug. The analytical techniques employed included ultraviolet–visible spectroscopy (UV–Vis), Fourier-transform infrared spectroscopy (FTIR), photoluminescence spectroscopy (PL), zeta potential measurement, and scanning electron microscopy (SEM).</p>

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Co-encapsulation of Vincristine and Vitamin E in Soy Lecithin/Hydrogenated Soy Lecithin Liposomes

  • 期刊论文

  • 发表日期：

    2025年1月2日

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  • A. G. Valdes-Becerril,
  • R. Jimenez-Rodriguez,
  • J. Douda,
  • B. El Filali,
  • I. C. Ballardo-Rodriguez,
  • I. C. Romero-Ibarra

摘要

In this study, liposomes were formulated using conventional soybean lecithin and hydrogenated soybean lecithin, combined with egg lecithin and cholesterol, all coated with polyethylene glycol (PEG) and loaded with vincristine. The liposomes exhibited an approximate size of 340 nm for those made with soybean lecithin and 244 nm for those using hydrogenated soybean lecithin. Their preparation was carried out through the lipid bilayer hydration method. To enhance the amount of encapsulated drug, vincristine was incorporated into a vitamin E (α-tocopherol) oil-in-water (O/W) emulsion. This approach aims to optimize the encapsulation efficiency of vincristine, prevent its degradation during the preparation process, and extend the drug's lifespan within the liposomes, thereby facilitating a controlled and sustained release at the target site, while also providing antioxidants as support in cancer therapy. Vitamin E is known for its instability, a challenge that can be mitigated by using α-tocopherol acetate, its esterified form. Thus, an emulsion-based delivery system may provide an alternative method for delivering lipid-soluble bioactive in combination with water-soluble compounds. Both formulations demonstrated an encapsulation efficiency exceeding 50%, with hydrogenated soybean lecithin showing greater stability and a higher quantity of encapsulated drug. The analytical techniques employed included ultraviolet–visible spectroscopy (UV–Vis), Fourier-transform infrared spectroscopy (FTIR), photoluminescence spectroscopy (PL), zeta potential measurement, and scanning electron microscopy (SEM).