MoS₂ Nanoflowers Impregnated Functionally Modified Amino Cellulose Nanocomposites: An Innovative Approach for Anticancer Therapeutics

The advancement of anticancer medications has progressed considerably over the years, fueled by the pressing necessity to tackle the intricate issues and difficulties related to cancer therapy. Cancer continues to be a significant cause of death globally, highlighting the need for ongoing research into effective treatment options. While considering the need for an effective treatment, microcrystalline cellulose (MCC) was modified to create amino cellulose (AC) derivatives, including 6-deoxy-6-hydrazide cellulose (C-Hyd), 6-deoxy-6-(N,N-diethyl)amine cellulose (C-DEA), and 6-deoxy-6-diethyltriamine cellulose (C-DETA). AC derivatives were used as supporting material for developing MoS₂ nanocomposite for cancer therapeutics. Characterization using FTIR and ¹H-NMR spectroscopy confirmed NH moieties and MoS₂ adsorption, while XRD and SEM–EDS analyses verified the crystalline structure and morphology. MoS₂ NF loading, swelling, and degradation rate of AC-MoS₂ nanocomposites have been investigated. AC-MoS₂ nanocomposites were analyzed against NIH3T3, B16F10, MDA-MB-231, and MCF-7 cell lines, using presto blue and LIVE/DEAD staining. Cell viability assay and fluorescence microscopy against four cell lines revealed that all AC-MoS₂ nanocomposites with 5 wt% MoS₂ exhibited selective cytotoxicity for cancer cell lines compared to fibroblast cell lines. Our findings indicated that amino cellulose derivatives loaded with MoS₂ could be efficient candidates for skin and breast cancer therapy.