<p>This study delves into the nanotechnology idea for the formulation of natural-based anti-quorum-sensing agents, particularly <i>Candida albicans</i>, a significant fungal pathogen. This research highlights how they may be generated and improved over traditional anti-quorum-sensing agents. The development of a metallic or green anti-quorum-sensing agent entails selecting the nature of the anti-quorum-sensing agent and formulating it into nanoparticles (polymeric, nanocapsule, nanosphere, solids, lipids), nanoemulsions, and nanocomposites using green science or green technology principles. The loading, entrapment effectiveness, and release profile may all be evaluated to determine the success of a nanosystem. Bioassay investigations utilizing the appropriate nano-formulation in the laboratory and on outdoor trails indicate the nano anti-quorum-sensing agent. Biocompatibility or biosafety must be evaluated using an appropriate in vitro and in vivo screening model system, such as cell lines or zebrafish models. This study demonstrates that the nano anti-quorum-sensing agent generated by green nanotechnology may potentially be used to eradicate the quorum sensing of microorganisms, including <i>Candida albicans</i>, in an eco-friendly and highly efficient method.</p> Graphical Abstract <p></p>