Synthesis and Analysis of Novel Polyamide COF-TH as a Potent Anticancer Delivery Vehicle Under Variable pH Conditions

In this work, novel polyamide inked covalent organic frameworks—terepthalde hydrazine (COF-TH)—have been explored for selected anticancer drug delivery applications (DDA). Initially, trimesoyl chloride and terepthalic dihydrazine were used to synthesize novel covalent organic frameworks—terepthalde dihydrazine (COF-TH) in 1,4 dioxane under standard room temperature (RT) conditions. Different microscopic and spectroscopic analysis techniques confirmed the novel lab. synthesized and unique structural confirmations COF-TH. Before exploring the drug release analysis, the cytotoxicity of COF-TH and selected drug@COF-TH was investigated in mouse fibroblast (L929) and human breast cancer cells (MCF-7) cell lines. The resultant porous structure is ideally suited for efficiently encapsulating three vital anticancer drugs: DOX, 5-FU, and cisplatin. Furthermore, drug release kinetics (DRK) study has been investigated through varying pH solutions from neutral to acidic medium. These findings underline COF-TH’s significant potential in advancing drug delivery systems, offering the promise of improved therapeutic interventions. With its dual functionality encompassing both drug delivery and inherent anticancer properties, COF-TH emerges as a powerful tool for elevating the outcomes of cancer treatment, presenting a multifaceted approach to advancing the field of oncology.