<p>Previous studies have developed biodiesel production methods from spent coffee grounds (SCGs) via ethanolic extraction and supercritical ethanol transesterification (EE-SET) to minimize the energy consumption associated with solvent evaporation. In this study, we perform a technoeconomic analysis (TEA) and a life cycle assessment (LCA) to evaluate the profitability and sustainability of EE-SET. The material and energy balances in the TEA and LCA were derived from Aspen Plus^® V12 based on experimental data from previous research. The results from the base case indicated that EE-SET was unprofitable and posed a considerable environmental burden by disposing of defatted SCG (DSCG) as solid waste due to two main issues. First, the amount of DSCG was 4.8 times greater than the total biodiesel and glycerol produced. Second, landfilling DSCG incurred waste treatment costs and induced greenhouse gas (GHG) emissions simultaneously. Selling DSCG as a feedstock for solid fuel pellets offers an effective strategy for achieving profitability and sustainability. As such, EE-SET addresses the economic drawback of generating profit from selling DSCG while reducing waste treatment costs. Using DSCG as a solid fuel for environmental benefits increases ash disposal credit and substantially reduces GHG emissions. The incorporation of pelletizing units or biomass power plants into EE-SET represents a promising avenue for future research.</p>