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Background <p>The Mediterranean diet is a nutritional approach reported to be beneficial in various diseases. We performed a systematic review about its role in the treatment of inflammatory bowel disease (IBD).</p> Methods <p>Electronic databases (PubMed, Embase and Scopus) were searched on 10th February 2025 to identify reports on the use of the Mediterranean diet in the treatment of IBD. We extracted data with respect to clinical response, remission and endoscopic and histological responses with the use of the Mediterranean diet in the treatment of IBD. Pooled clinical response rates and remission rates were calculated.</p> Results <p>Eight studies were eventually included<b>.</b> Seven studies involving 223 participants provided information about the induction of remission. The pooled clinical remission rate with Mediterranean diet was 0.62 (95% CI = 0.39–0.80, <i>I</i><sup>2</sup> = 78.6%). A sub-group analysis showed similar remission rates for Crohn’s disease (CD) (RR = 0.67, 95% CI = 0.38; 0.87) and ulcerative colitis (0.56, 95% CI = 0.24–0.84), (<i>p</i> = 0.7531). Compared to control diets, Mediterranean diet showed no significant advantage in inducing remission (pooled OR = 0.98, 95% CI = 0.74–1.30, <i>I</i><sup>2</sup> = 42.9%). No studies reported outcomes for endoscopic or histological responses.</p> Conclusion <p>The Mediterranean diet in conjunction with standard medical therapy is associated with a clinical remission rate of approximately 62% in IBD, with comparable efficacy in CD and ulcerative colitis. The studies on Mediterranean diet are compromized by heterogenous study, definitions&#xa0;of disease activity and outcomes and concurrent use of medical therapies. Further high-quality randomized trials are needed to evaluate the impact of the Mediterranean diet on objective disease markers and long-term outcomes in IBD.</p> Graphical Abstract <p></p>

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Mediterranean diet in treatment of inflammatory bowel disease: A systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2026年3月9日

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  • Arjun Singh,
  • Urvashi Rana,
  • Sanjay Chandnani,
  • Arshdeep Singh,
  • Dawesh P. Yadav,
  • Himanshu Narang,
  • Kiran Josy,
  • Tarini Shankar Ghosh,
  • Abhirup Chatterjee,
  • Saurabh Kedia,
  • Mathew Phillip,
  • Ajit Sood,
  • Vineet Ahuja,
  • Vishal Sharma

摘要

Background

The Mediterranean diet is a nutritional approach reported to be beneficial in various diseases. We performed a systematic review about its role in the treatment of inflammatory bowel disease (IBD).

Methods

Electronic databases (PubMed, Embase and Scopus) were searched on 10th February 2025 to identify reports on the use of the Mediterranean diet in the treatment of IBD. We extracted data with respect to clinical response, remission and endoscopic and histological responses with the use of the Mediterranean diet in the treatment of IBD. Pooled clinical response rates and remission rates were calculated.

Results

Eight studies were eventually included. Seven studies involving 223 participants provided information about the induction of remission. The pooled clinical remission rate with Mediterranean diet was 0.62 (95% CI = 0.39–0.80, I2 = 78.6%). A sub-group analysis showed similar remission rates for Crohn’s disease (CD) (RR = 0.67, 95% CI = 0.38; 0.87) and ulcerative colitis (0.56, 95% CI = 0.24–0.84), (p = 0.7531). Compared to control diets, Mediterranean diet showed no significant advantage in inducing remission (pooled OR = 0.98, 95% CI = 0.74–1.30, I2 = 42.9%). No studies reported outcomes for endoscopic or histological responses.

Conclusion

The Mediterranean diet in conjunction with standard medical therapy is associated with a clinical remission rate of approximately 62% in IBD, with comparable efficacy in CD and ulcerative colitis. The studies on Mediterranean diet are compromized by heterogenous study, definitions of disease activity and outcomes and concurrent use of medical therapies. Further high-quality randomized trials are needed to evaluate the impact of the Mediterranean diet on objective disease markers and long-term outcomes in IBD.

Graphical Abstract