Scholarlink

Introduction <p>Bile duct injury (BDI) is a potentially devastating complication of cholecystectomy. Although the repair may be successful, patients often experience a decline in their quality of life (QoL). However, there is a paucity of data regarding the factors influencing long-term outcomes and QOL in these patients.</p> Methods <p>Patients who underwent benign biliary stricture (BBS) repair with at least three&#xa0;years of follow-up were assessed for inclusion in the study. Long-term outcomes were assessed with MacDonald Grading. QOL assessed using the SF-36 questionnaire, with a control group of patients who had uncomplicated laparoscopic cholecystectomy (LC).</p> Results <p>Of 156&#xa0;patients screened, 41 were included in the study, with a median follow-up duration of&#xa0;five (IQR 4.8) years. Successful long-term outcomes with MacDonald outcome grade A were observed in 28 (68.3%) patients, 12 (29.2%) patients had grade B and one (2.4%) had grade-D outcomes. External biliary fistula at the time of repair had grade-D outcome in one patient (14.2%) and grades B and A in three (42.9%) patients each. The higher strictures (types IV and V) were associated with higher&#xa0;MacDonald&#xa0;grade-B outcomes compared to types I–III strictures (7 [53.8%] vs. 5 [17.9%]) , whereas lower strictures were more likely to have grade-A outcomes as compared to higher strictures (22 [78.6%] vs. 6 [46.2%] [<i>p</i> = 0.044]). Patients with BDI repair reported significantly lower scores in all eight SF-36 domains compared to controls (<i>p</i> &lt; 0.05).</p> Conclusion <p>The long-term outcomes of delayed BBS repair are favorable in high-volume center. Despite the acceptable post operative clinical outcomes, the long-term QOL remains compromised after BBS repairs.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Long-term outcomes and quality of life after repair of benign biliary stricture of post-cholecystectomy bile duct injury

  • 期刊论文

  • 发表日期：

    2025年9月8日

查看全文
  • Jyoti Kharel,
  • Thakur Deen Yadav,
  • Rajesh Gupta,
  • Harjeet Singh

摘要

Introduction

Bile duct injury (BDI) is a potentially devastating complication of cholecystectomy. Although the repair may be successful, patients often experience a decline in their quality of life (QoL). However, there is a paucity of data regarding the factors influencing long-term outcomes and QOL in these patients.

Methods

Patients who underwent benign biliary stricture (BBS) repair with at least three years of follow-up were assessed for inclusion in the study. Long-term outcomes were assessed with MacDonald Grading. QOL assessed using the SF-36 questionnaire, with a control group of patients who had uncomplicated laparoscopic cholecystectomy (LC).

Results

Of 156 patients screened, 41 were included in the study, with a median follow-up duration of five (IQR 4.8) years. Successful long-term outcomes with MacDonald outcome grade A were observed in 28 (68.3%) patients, 12 (29.2%) patients had grade B and one (2.4%) had grade-D outcomes. External biliary fistula at the time of repair had grade-D outcome in one patient (14.2%) and grades B and A in three (42.9%) patients each. The higher strictures (types IV and V) were associated with higher MacDonald grade-B outcomes compared to types I–III strictures (7 [53.8%] vs. 5 [17.9%]) , whereas lower strictures were more likely to have grade-A outcomes as compared to higher strictures (22 [78.6%] vs. 6 [46.2%] [p = 0.044]). Patients with BDI repair reported significantly lower scores in all eight SF-36 domains compared to controls (p < 0.05).

Conclusion

The long-term outcomes of delayed BBS repair are favorable in high-volume center. Despite the acceptable post operative clinical outcomes, the long-term QOL remains compromised after BBS repairs.

Graphical Abstract