Clinical outcomes and reintervention after endoscopic retrograde cholangiopancreatography in primary sclerosing cholangitis in absence of cholangitis

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2024年7月12日

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Ryosuke Horio,
Jun Kato,
Takashi Taida,
Yuki Ohta,
Keiko Saito,
Yuhei Oyama,
Hayato Nakazawa,
Yukiyo Mamiya,
Chihiro Goto,
Satsuki Takahashi,
Mayu Ouchi,
Akane Kurosugi,
Michiko Sonoda,
Motoyasu Kan,
Tatsuya Kaneko,
Hiroki Nagashima,
Naoki Akizue,
Koji Takahashi,
Kenichiro Okimoto,
Hiroshi Ohyama,
Tomoaki Matsumura,
Izumi Ohno,
Naoya Kato

摘要

Background and Aim

Endoscopic retrograde cholangiopancreatography (ERCP) may help detect cholangiocarcinoma in patients with primary sclerosing cholangitis (PSC), but it may be associated with complications. This study was aimed at determining the prognostic impact of ERCP on patients with PSC without cholangitis.

Methods

Patients with PSC without cholangitis were divided into two groups: those who underwent ERCP within three years after diagnosis (ERCP-performed group) and those who did not (non-ERCP group). These groups were compared in terms of clinical outcomes (liver-related death or liver transplantation, endoscopic treatment requirement and repeated cholangitis) and the composite outcome.

Results

Of 99 patients with PSC with detailed medical history, 49 were included in the ERCP-performed group and 21 in the non-ERCP group. In Kaplan-Meier analysis, the non-ERCP group was less likely to achieve the three outcomes and the composite outcome, showing statistical significance (endoscopic treatment requirement; p = 0.017 and composite outcome; p = 0.014). A Cox proportional hazards model indicated that ERCP in the asymptomatic state was a significant predictor of endoscopic treatment requirement (hazard ratio [HR]: 4.37, 95% confidence interval [CI]: 1.03–18.59) and the composite outcome (HR: 4.54, 95% CI: 1.07–19.28).

Conclusion

ERCP in patients with PSC without cholangitis is likely to require further endoscopic treatment and may be associated with poor prognosis.

Graphical Abstract