Introduction <p>Maxillofacial trauma, frequently resulting from motor vehicle accidents, is associated with both physical and psychological consequences for patients. In Malaysia, particularly Pahang, there is limited research on the psychological impact following such injuries. This study aims to address this gap by evaluating the prevalence and contributing factors of anxiety and depression among maxillofacial trauma patients.</p> Methods <p>A prospective cohort study was conducted across two main hospitals in Pahang, Malaysia, from December 2020 to December 2022. Anxiety and depression levels of 192 patients were assessed at 1-week, 1-month, and 3-month intervals post-trauma using the Malaysian version of the Hospital Anxiety and Depression Scale (HADS-M). Multiple factors such as demographic and clinical characteristics were analyzed for their association with psychological outcomes.</p> Results <p>Anxiety and depression levels generally improved over time. While females, older patients and those with jaw fractures or maxillomandibular fixation (MMF) reported higher initial anxiety and depression scores, only jaw fractures and maxillomandibular fixation (MMF) showed significant associations.</p> Conclusion <p>In conclusion, anxiety and depression levels among patients with maxillofacial trauma showed a general improvement trend over the 3 month follow up period. Injury severity and treatment modality may impact short term anxiety and depression following maxillofacial trauma.</p>