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Introduction <p>Odontogenic space infections can progress rapidly, leading to serious complications such airway obstruction, sepsis, or multi-organ dysfunction. Acute phase reactants (APRs), such as total leukocyte count (TLC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum procalcitonin (PCT), are key markers of inflammation used to assess the severity of infection and monitor treatment response. This study evaluates these biomarkers in patients with odontogenic space infections and their correlation with clinical outcomes.</p> Aims and objectives <p>To assess preoperative and postoperative levels of TLC, ESR, CRP, and PCT to determine infection severity and the effectiveness of antibiotic therapy in patients with odontogenic space infections.Methods: This study included 32 patients diagnosed with odontogenic space infections requiring incision, drainage, and tooth extraction. Blood investigations including TLC, ESR, CRP, and serum procalcitonin were performed preoperatively and postoperatively</p> Results <p>Postoperative CRP levels showed a significant reduction from 58.2 ± 28.1 to 26.2 ± 14.3 mg/L. ESR and TLC levels also demonstrated a significant decline following treatment. Serum procalcitonin levels showed a downward trend postoperatively. Receiver operating characteristic analysis, performed between sepsis and non-sepsis groups, demonstrated variation in diagnostic performance, with procalcitonin showing higher discriminatory ability (AUC 0.956), whereas CRP, ESR, and TLC showed lower discriminatory values (AUC approximately 0.46).</p> Conclusion <p>Serum procalcitonin demonstrated notable discriminatory performance in the assessment of sepsis. Further studies with larger sample sizes are recommended to validate these observations and explore the role of emerging biomarkers in sepsis.</p>

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A Prospective Study to Evaluate the Role of Acute Phase Reactants in the Management of Odontogenic Space Infections

  • 期刊论文

  • 发表日期：

    2026年7月21日

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  • Damini,
  • Nitin Verma,
  • Puneet Girdhar,
  • Karan Kumar,
  • Dev Ansh Verma

摘要

Introduction

Odontogenic space infections can progress rapidly, leading to serious complications such airway obstruction, sepsis, or multi-organ dysfunction. Acute phase reactants (APRs), such as total leukocyte count (TLC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum procalcitonin (PCT), are key markers of inflammation used to assess the severity of infection and monitor treatment response. This study evaluates these biomarkers in patients with odontogenic space infections and their correlation with clinical outcomes.

Aims and objectives

To assess preoperative and postoperative levels of TLC, ESR, CRP, and PCT to determine infection severity and the effectiveness of antibiotic therapy in patients with odontogenic space infections.Methods: This study included 32 patients diagnosed with odontogenic space infections requiring incision, drainage, and tooth extraction. Blood investigations including TLC, ESR, CRP, and serum procalcitonin were performed preoperatively and postoperatively

Results

Postoperative CRP levels showed a significant reduction from 58.2 ± 28.1 to 26.2 ± 14.3 mg/L. ESR and TLC levels also demonstrated a significant decline following treatment. Serum procalcitonin levels showed a downward trend postoperatively. Receiver operating characteristic analysis, performed between sepsis and non-sepsis groups, demonstrated variation in diagnostic performance, with procalcitonin showing higher discriminatory ability (AUC 0.956), whereas CRP, ESR, and TLC showed lower discriminatory values (AUC approximately 0.46).

Conclusion

Serum procalcitonin demonstrated notable discriminatory performance in the assessment of sepsis. Further studies with larger sample sizes are recommended to validate these observations and explore the role of emerging biomarkers in sepsis.