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Introduction <p>Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm, with approximately 20% of cases arising in the head and neck (H&amp;N) region. Surgical excision with microscopically negative margins (R0 resection) represents the standard treatment; however, local recurrence and distant metastasis may occur. The aim of this single-institution retrospective study was to analyze the clinical characteristics, diagnostic workup, surgical management, and oncological outcomes of patients with H&amp;N SFT.</p> Materials and Methods <p>A single-institution retrospective observational study was conducted in the Department of Maxillofacial Surgery, Policlinico Umberto I, Rome, including patients with H&amp;N SFT who underwent surgical treatment over a 10-year period.</p> Results <p>Thirteen patients met the inclusion criteria. Malignant histopathological features were observed in 5 patients (39%). Postoperative radiotherapy was administered in 3 cases (23%). At the last follow-up, 8 patients (62%) were disease-free, 2 (15%) had persistent disease, 2 (15%) were lost to follow-up, and 1 patient (8%) died of unrelated causes.</p> Conclusion <p>Durable disease control was primarily achieved through complete tumor removal whenever anatomically feasible. Long-term follow-up is recommended due to the risk of late recurrence. Adjuvant radiotherapy may represent a reasonable option in selected high-risk or margin-positive cases.</p>

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Solitary Fibrous Tumors of the Head and Neck: A 10-Year Single-Institution Retrospective Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月22日

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  • Andrea Cassoni,
  • Giulia Scivoletto,
  • Cira Rosaria Tiziana Di Gioia,
  • Francesca Galvano,
  • Angela Palma,
  • Resi Pucci,
  • Marco Della Monaca,
  • Valentino Valentini

摘要

Introduction

Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm, with approximately 20% of cases arising in the head and neck (H&N) region. Surgical excision with microscopically negative margins (R0 resection) represents the standard treatment; however, local recurrence and distant metastasis may occur. The aim of this single-institution retrospective study was to analyze the clinical characteristics, diagnostic workup, surgical management, and oncological outcomes of patients with H&N SFT.

Materials and Methods

A single-institution retrospective observational study was conducted in the Department of Maxillofacial Surgery, Policlinico Umberto I, Rome, including patients with H&N SFT who underwent surgical treatment over a 10-year period.

Results

Thirteen patients met the inclusion criteria. Malignant histopathological features were observed in 5 patients (39%). Postoperative radiotherapy was administered in 3 cases (23%). At the last follow-up, 8 patients (62%) were disease-free, 2 (15%) had persistent disease, 2 (15%) were lost to follow-up, and 1 patient (8%) died of unrelated causes.

Conclusion

Durable disease control was primarily achieved through complete tumor removal whenever anatomically feasible. Long-term follow-up is recommended due to the risk of late recurrence. Adjuvant radiotherapy may represent a reasonable option in selected high-risk or margin-positive cases.