Background <p>Oral lichen planus (OLP) is a chronic autoimmune disorder affecting 1–2% of adults. Although dyslipidemia has been widely associated with autoimmune diseases, its relationship with OLP and its clinical subtypes remains unclear. This study aimed to evaluate serum lipid parameters in OLP patients compared with healthy controls and to assess variations across clinical subtypes.</p> Materials and Methods <p>A case–control study included 20 OLP cases and 20 age- and gender-matched healthy controls. OLP was categorized into reticular-papular (R/P) and atrophic-erosive (A/E) subtypes. Serum lipid parameters, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and Non-HDL, were analyzed, and appropriate statistical tests were performed.</p> Results <p>OLP cases exhibited elevated TC, TG, LDL, VLDL, and Non-HDL cholesterol levels compared to the controls (<i>p</i> &lt; 0.001), while HDL showed no significant difference. Additionally, these lipid parameters, excluding HDL showed significant increase in A/E OLP subtypes than R/P OLP (<i>p</i> &lt; 0.00). Dyslipidemia was present in 80% of OLP cases, indicating increased cardiovascular risk.</p> Conclusions <p>The present study findings suggest a possible association between dyslipidemia and OLP, including its clinical subtypes. The potential role of lipid parameters as biomarkers of disease activity requires further validation.</p>