Objective <p>Multi-stage “dredging” approach was applied to adolescent patients suffering from large solid mandibular ameloblastoma with mural invasion and finally satisfactory results was achieved. The purpose of this report is to review this technique and to share our experience leading to success in six case series.</p> Materials and methods <p>Six patients who were diagnosed with cone beam computerized tomography (CBCT), intraoperative frozen examination, and finally confirmed by pathological examination postoperatively. The lesions were large and no fluid was detected by needle aspiration. Owing to solid type and serious bone destruction, multi-stage “dredging” treatment was applied after serious consideration and careful preparation in order to avoid significant complications. The dredging protocol was performed and the details were shared in our study. Patients were followed up every 6 months after the last surgery to assess whether the lesion had recurred or whether there was a change in facial contour. This research was a prospective clinical study.</p> Results <p>Two years later, CBCT showed disappearance of the lesion and a large amount of new bone formation with normal bone contour. During the subsequent 5 to 8 years follow-up period, there were no postoperative complications such as lower lip numbness and no recurrence. The patients’ facial swelling resolved, and the faces were essentially symmetrical.</p> Conclusion <p>The conservative multi-stage dredging method might be a viable option for the treatment of large solid ameloblastoma, especially in younger patients, however, some techniques need to be carefully considered to achieve success.</p>