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Background <p>Temporomandibular joint disorders can be managed using both conservative and surgical modalities. Conservative approaches are generally considered the first-line treatment. Hypertonic dextrose prolotherapy is one of the injectable options used in the management of these disorders, particularly in cases refractory to conservative therapy.</p> Aim <p>This study was aimed to evaluate the effectiveness of a single-session prolotherapy injection in patients with temporomandibular joint derangement (chronic joint pain and sounds).</p> Materials and Methods <p>This prospective comparative clinical study included 50 patients presenting with severe pain and joint sounds during functional jaw movement. Patients were equally divided into two groups: Group A (blind injection technique) and Group B (ultrasound-guided injection). Each patient received 2 mL of 50% hypertonic dextrose solution as a single injection. Pain (the visual analog scale) and joint sounds (binary outcome) were evaluated at 4, 8, and 12 weeks.</p> Results <p>Both groups demonstrated a significant reduction in pain and joint sounds over the follow-up period, with no statistically significant difference between the two techniques.</p> Conclusion <p>Single-session dextrose prolotherapy demonstrated short-term clinical improvement in pain and joint sounds. It may represent a safe and minimally invasive treatment option; however, further studies with larger sample sizes, longer follow-up periods, and objective outcome measures are required to confirm these findings.</p>

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Single-Session Dextrose Prolotherapy for Painful Temporomandibular Joint Internal Derangement with Joint Sounds: A Prospective Comparative Study of Ultrasound-Guided and Blind Injection Techniques

  • 期刊论文

  • 发表日期：

    2026年6月23日

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  • Thair Abdel Lateef Hassan,
  • Safaa Riyadh,
  • Heba Basim Mohammed,
  • Lobaba Basim Mohammed

摘要

Background

Temporomandibular joint disorders can be managed using both conservative and surgical modalities. Conservative approaches are generally considered the first-line treatment. Hypertonic dextrose prolotherapy is one of the injectable options used in the management of these disorders, particularly in cases refractory to conservative therapy.

Aim

This study was aimed to evaluate the effectiveness of a single-session prolotherapy injection in patients with temporomandibular joint derangement (chronic joint pain and sounds).

Materials and Methods

This prospective comparative clinical study included 50 patients presenting with severe pain and joint sounds during functional jaw movement. Patients were equally divided into two groups: Group A (blind injection technique) and Group B (ultrasound-guided injection). Each patient received 2 mL of 50% hypertonic dextrose solution as a single injection. Pain (the visual analog scale) and joint sounds (binary outcome) were evaluated at 4, 8, and 12 weeks.

Results

Both groups demonstrated a significant reduction in pain and joint sounds over the follow-up period, with no statistically significant difference between the two techniques.

Conclusion

Single-session dextrose prolotherapy demonstrated short-term clinical improvement in pain and joint sounds. It may represent a safe and minimally invasive treatment option; however, further studies with larger sample sizes, longer follow-up periods, and objective outcome measures are required to confirm these findings.