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Objectives <p>To evaluate the polymorphisms of RETN + 62 and RETN + 420 genes in different grades of oral submucous fibrosis (OSMF) in a North Indian population.</p> Study Design <p>Thirty OSMF patients of various grades were recruited at a tertiary healthcare centre in Northern India. Blood samples were analyzed for RETN + 62 and RETN + 420 gene variants using Polymerase Chain Reaction (PCR). Chi-square (χ<sup>2</sup>) tests assessed associations between genotypes and factors such as age, habits, and OSMF grades. Stepwise linear regression evaluated the influence of independent variables on RETN polymorphisms.</p> Results <p>The RETN + 62 GG genotype was the most prevalent (66.67%) and was predominantly associated with advanced OSMF grades (3/4), with lower frequency in grades 1/2. This genotype was more common in patients with combined chewing and smoking habits compared to those with chewing-only habits. No statistically significant association was observed for RETN + 420 polymorphisms.</p> Conclusion <p>The RETN + 62 GG genotype is associated with advanced OSMF grades in this cohort, highlighting its potential as a biomarker for disease severity. The study did not include healthy controls, preventing assessment of whether the observed prevalence of the + 62 GG genotype reflects background population genetics or disease-related enrichment. Future multicentric studies incorporating healthy controls, functional assays, and longitudinal follow-up are essential to validate RETN-62 as a clinically useful biomarker in OSMF.</p>

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Resistin Gene Polymorphisms: A Potential Biomarker for Severity of Oral Submucous Fibrosis (OSMF)—A Pilot Study from a Tertiary Care Centre in North India

  • 期刊论文

  • 发表日期：

    2026年4月24日

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  • Roop Ganguly,
  • Vibha Singh,
  • Anupama Mukherjee,
  • Nitu Nigam,
  • Deepika Jain,
  • Angela Hancock,
  • Conrad Orori,
  • Colin Hopper

摘要

Objectives

To evaluate the polymorphisms of RETN + 62 and RETN + 420 genes in different grades of oral submucous fibrosis (OSMF) in a North Indian population.

Study Design

Thirty OSMF patients of various grades were recruited at a tertiary healthcare centre in Northern India. Blood samples were analyzed for RETN + 62 and RETN + 420 gene variants using Polymerase Chain Reaction (PCR). Chi-square (χ2) tests assessed associations between genotypes and factors such as age, habits, and OSMF grades. Stepwise linear regression evaluated the influence of independent variables on RETN polymorphisms.

Results

The RETN + 62 GG genotype was the most prevalent (66.67%) and was predominantly associated with advanced OSMF grades (3/4), with lower frequency in grades 1/2. This genotype was more common in patients with combined chewing and smoking habits compared to those with chewing-only habits. No statistically significant association was observed for RETN + 420 polymorphisms.

Conclusion

The RETN + 62 GG genotype is associated with advanced OSMF grades in this cohort, highlighting its potential as a biomarker for disease severity. The study did not include healthy controls, preventing assessment of whether the observed prevalence of the + 62 GG genotype reflects background population genetics or disease-related enrichment. Future multicentric studies incorporating healthy controls, functional assays, and longitudinal follow-up are essential to validate RETN-62 as a clinically useful biomarker in OSMF.