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Background <p>Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is an uncommon benign lesion of the oral mucosa that may clinically mimic malignancy.</p> Case Presentation <p>We report a case of a 76-year-old female presenting with a painful non-healing ulcer on the left lateral border of the tongue associated with difficulty in chewing. Clinical examination revealed a well-defined ulcer with indurated margins adjacent to sharp tooth structures.</p> Management and Outcome <p>Because of the clinical suspicion of malignancy, an incisional biopsy was performed. Histopathological examination showed ulcerated mucosa with dense inflammatory infiltrate rich in eosinophils, consistent with TUGSE, with no evidence of malignancy. The lesion was managed by surgical excision and elimination of local traumatic factors, resulting in complete healing.</p> Conclusion <p>This case highlights the importance of histopathological evaluation in persistent oral ulcers that clinically resemble squamous cell carcinoma, thereby preventing misdiagnosis and unnecessary aggressive treatment.</p>

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TUGSE of the Tongue Mimicking Oral Malignancy: A Diagnostic Pitfall

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Saurabh R. Nagar,
  • Jeevika G.,
  • Prachi R. Bhandare,
  • Srishti S. Talkar,
  • Gabriela Fernandes

摘要

Background

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is an uncommon benign lesion of the oral mucosa that may clinically mimic malignancy.

Case Presentation

We report a case of a 76-year-old female presenting with a painful non-healing ulcer on the left lateral border of the tongue associated with difficulty in chewing. Clinical examination revealed a well-defined ulcer with indurated margins adjacent to sharp tooth structures.

Management and Outcome

Because of the clinical suspicion of malignancy, an incisional biopsy was performed. Histopathological examination showed ulcerated mucosa with dense inflammatory infiltrate rich in eosinophils, consistent with TUGSE, with no evidence of malignancy. The lesion was managed by surgical excision and elimination of local traumatic factors, resulting in complete healing.

Conclusion

This case highlights the importance of histopathological evaluation in persistent oral ulcers that clinically resemble squamous cell carcinoma, thereby preventing misdiagnosis and unnecessary aggressive treatment.