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Introduction <p>Recent advances in understanding the biological features of Odontogenic Keratocysts provide evidence of the benefits of conservative surgical treatment, which is not only affordable but also preserves structural and functional integrity. Several studies have demonstrated the benefits of 5-Fluorouracil [Fu], a chemotherapeutic agent, in the treatment of Odontogenic Keratocysts [OKCs].</p> Aim <p>This study aims to compare 5-Fluorouracil with Modified Carnoy’s Solution [MCS] in the conservative management of OKC.</p> Materials and Methods <p>The study was conducted with 3 main objectives: To evaluate the recurrence rate, the incidence of nerve paresthesia, healing of underlying pathology. The authors had put forth a new protocol for the application of 5-Fu, and a few of the cases were managed under the new protocol.</p> Results <p>The results suggest that 5-Fu is a promising adjunctive modality showing favorable clinical outcomes with no recurrences and a lower incidence of nerve paresthesia in this limited cohort within the scope of our study.</p> Conclusion <p>Further studies with larger cohorts and with larger follow-ups are required to conclusively prove the effects of 5-Fu in OKC and affirm the new protocol for better useof 5-Fu in the management of OKCs.</p>

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Topical 5—Fluorouracil as a Novel Adjunctive Therapy for Odontogenic Keratocyst—An Ambispective Observational Study

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Varsha Manekar,
  • Priyanka Shetty,
  • Abhay Datarkar

摘要

Introduction

Recent advances in understanding the biological features of Odontogenic Keratocysts provide evidence of the benefits of conservative surgical treatment, which is not only affordable but also preserves structural and functional integrity. Several studies have demonstrated the benefits of 5-Fluorouracil [Fu], a chemotherapeutic agent, in the treatment of Odontogenic Keratocysts [OKCs].

Aim

This study aims to compare 5-Fluorouracil with Modified Carnoy’s Solution [MCS] in the conservative management of OKC.

Materials and Methods

The study was conducted with 3 main objectives: To evaluate the recurrence rate, the incidence of nerve paresthesia, healing of underlying pathology. The authors had put forth a new protocol for the application of 5-Fu, and a few of the cases were managed under the new protocol.

Results

The results suggest that 5-Fu is a promising adjunctive modality showing favorable clinical outcomes with no recurrences and a lower incidence of nerve paresthesia in this limited cohort within the scope of our study.

Conclusion

Further studies with larger cohorts and with larger follow-ups are required to conclusively prove the effects of 5-Fu in OKC and affirm the new protocol for better useof 5-Fu in the management of OKCs.