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Background <p>Tramadol hydrochloride (T-HCL) has shown potential local anesthetic properties but its efficacy in dental extraction remains unclear. This study aimed to compare the local anesthetic effect of tramadol with that of lignocaine hydrochloride (L-HCL) in the extraction of maxillary anterior teeth.</p> Materials and methods <p>It was a randomized, double-blind, controlled trial. Patients aged 18–60 years, requiring extraction of one or more maxillary anterior teeth were included in the study. The patients were assigned into two groups: Group A received 1.8&#xa0;ml of 5% T-HCL and Group B received 1.8&#xa0;ml of 2% L-HCL without adrenaline, respectively. Amount of anesthesia administered, onset of anesthesia, and intraoperative pain were evaluated using unpaired t tests.</p> Results <p>Forty patients were enrolled. The study results revealed that the amount of anesthesia required was higher in the tramadol group than in the lignocaine group. The onset of anesthesia was faster in the tramadol group (4.5 ± 0.88&#xa0;min) compared to the lignocaine group (5.35 ± 0.87&#xa0;min) Intraoperative pain, measured using the Visual Analog Scale (VAS), was slightly higher in the tramadol group (0.85 ± 0.78&#xa0;min) compared to the lignocaine group (0.5 ± 0.4&#xa0;min).</p> Conclusion <p>Tramadol has less potent, higher dose is required for the desired anesthetic property which cannot be recommended as a first-line anesthetic. However, it can be considered as alternative drug for patients who are allergic to lignocaine or other conventional local anesthetics.</p>

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Tramadol hydrochloride vs. lignocaine hydrochloride in the extraction of anterior teeth: a randomised comparative study

  • 期刊论文

  • 发表日期：

    2026年3月13日

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  • Srishti Agarwal,
  • Saravanan Lakshmanan,
  • Murugesan Krishnan,
  • Gidean Arularasan

摘要

Background

Tramadol hydrochloride (T-HCL) has shown potential local anesthetic properties but its efficacy in dental extraction remains unclear. This study aimed to compare the local anesthetic effect of tramadol with that of lignocaine hydrochloride (L-HCL) in the extraction of maxillary anterior teeth.

Materials and methods

It was a randomized, double-blind, controlled trial. Patients aged 18–60 years, requiring extraction of one or more maxillary anterior teeth were included in the study. The patients were assigned into two groups: Group A received 1.8 ml of 5% T-HCL and Group B received 1.8 ml of 2% L-HCL without adrenaline, respectively. Amount of anesthesia administered, onset of anesthesia, and intraoperative pain were evaluated using unpaired t tests.

Results

Forty patients were enrolled. The study results revealed that the amount of anesthesia required was higher in the tramadol group than in the lignocaine group. The onset of anesthesia was faster in the tramadol group (4.5 ± 0.88 min) compared to the lignocaine group (5.35 ± 0.87 min) Intraoperative pain, measured using the Visual Analog Scale (VAS), was slightly higher in the tramadol group (0.85 ± 0.78 min) compared to the lignocaine group (0.5 ± 0.4 min).

Conclusion

Tramadol has less potent, higher dose is required for the desired anesthetic property which cannot be recommended as a first-line anesthetic. However, it can be considered as alternative drug for patients who are allergic to lignocaine or other conventional local anesthetics.