Introduction <p>As surgical and anesthetic techniques advance, more infants with cleft palates undergo surgery at earlier ages. This progress, however, is accompanied by an increased risk of airway complications like obstruction and edema. Consequently, thorough preoperative evaluation of the upper airway in cleft palate patients is crucial.</p> Objective <p>To explore the three-dimensional morphology of the upper airway in infants with cleft palate.</p> Materials and Methods <p>Twenty-two patients diagnosed with cleft palate were examined, and upper airway models were reconstructed. The maxillofacial bone morphology and total volume of the upper airway, nasopharynx and oropharynx were measured. The hyoid vertebral distance (HVD) and adenoid thickness (AT) were analyzed together. <i>P</i>&lt;0.05 was considered to indicate statistical significance.</p> Results <p>The total volume of the upper airway and the oropharyngeal volume in cleft palate infants were significantly lower than those in normal infants, whereas the nasopharyngeal volume was not significantly different. The measurements of craniofacial morphology in cleft palate infants were significantly lower than those in normal infants. Nevertheless, there was no significant difference in HVD or AT.</p> Conclusion <p>Oropharyngeal volume, other than AT volume and HVD volume, is the main factor affecting the airway in infancy with cleft palate.</p>