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<p>Atypical histiocytic granuloma is an uncommon reactive benign condition that clinically and histologically may mimic malignant neoplasms such as squamous cell carcinoma or lymphoma but tends to regress spontaneously. The lesion has been described in various intra-oral sites, however, involvement of the tongue is rarely reported, with only five cases reported so far. Here, we report a rare case of atypical histiocytic granuloma affecting the lateral border of the tongue in a fifty-six-year-old female patient, with immunohistochemical analysis and an updated literature review.</p>

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Atypical Histiocytic Granuloma of Lateral Border of the Tongue: Report of a Rare Case and Literature Review

  • 期刊论文

  • 发表日期：

    2026年1月5日

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  • Deepak Pandiar,
  • Reshma Poothakulath Krishnan

摘要

Atypical histiocytic granuloma is an uncommon reactive benign condition that clinically and histologically may mimic malignant neoplasms such as squamous cell carcinoma or lymphoma but tends to regress spontaneously. The lesion has been described in various intra-oral sites, however, involvement of the tongue is rarely reported, with only five cases reported so far. Here, we report a rare case of atypical histiocytic granuloma affecting the lateral border of the tongue in a fifty-six-year-old female patient, with immunohistochemical analysis and an updated literature review.