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Introduction <p>Myoepithelial carcinoma (MC) is a rare salivary gland malignancy, accounting for less than 1% of all salivary neoplasms. Its occurrence in the minor salivary glands of the hard palate is exceedingly uncommon and often poses a diagnostic challenge due to its histological heterogeneity and resemblance to benign lesions.</p> Case Report <p>A 38-year-old male presented with a progressive swelling of the right midface and hard palate. Imaging revealed a locally advanced lesion involving the nasal cavity, maxillary sinus, and orbital floor. Histopathological evaluation with immunohistochemistry (SOX10, SMA) confirmed the diagnosis of MC. The patient received neoadjuvant chemotherapy (paclitaxel, cisplatin, and 5-fluorouracil), followed by total maxillectomy, bilateral modified radical neck dissection, and anterolateral thigh free flap reconstruction. Postoperative adjuvant radiotherapy was administered. The patient remains disease-free after 14 months, with satisfactory functional and aesthetic outcomes.</p> Conclusion <p>This case underscores the importance of early diagnosis, immunohistochemical confirmation, and a multidisciplinary approach in managing aggressive and rare minor salivary gland tumours. Neoadjuvant chemotherapy may aid in achieving negative surgical margins and optimizing outcomes in select advanced cases.</p>

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Uncommon Case of Myoepithelial Carcinoma in the Hard Palate: Diagnostic Insights & Multidisciplinary Management

  • 期刊论文

  • 发表日期：

    2025年12月3日

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  • Akshay K. Nadkarni,
  • Harshadkumar J. Nakum,
  • Pratik Agrawal,
  • Saibharath Susarla,
  • Rituparna Mitra,
  • Pranav Desai,
  • Ojas Desai

摘要

Introduction

Myoepithelial carcinoma (MC) is a rare salivary gland malignancy, accounting for less than 1% of all salivary neoplasms. Its occurrence in the minor salivary glands of the hard palate is exceedingly uncommon and often poses a diagnostic challenge due to its histological heterogeneity and resemblance to benign lesions.

Case Report

A 38-year-old male presented with a progressive swelling of the right midface and hard palate. Imaging revealed a locally advanced lesion involving the nasal cavity, maxillary sinus, and orbital floor. Histopathological evaluation with immunohistochemistry (SOX10, SMA) confirmed the diagnosis of MC. The patient received neoadjuvant chemotherapy (paclitaxel, cisplatin, and 5-fluorouracil), followed by total maxillectomy, bilateral modified radical neck dissection, and anterolateral thigh free flap reconstruction. Postoperative adjuvant radiotherapy was administered. The patient remains disease-free after 14 months, with satisfactory functional and aesthetic outcomes.

Conclusion

This case underscores the importance of early diagnosis, immunohistochemical confirmation, and a multidisciplinary approach in managing aggressive and rare minor salivary gland tumours. Neoadjuvant chemotherapy may aid in achieving negative surgical margins and optimizing outcomes in select advanced cases.