Background <p>The treatment of odontogenic infections is complex and may require prolonged hospitalization and multiple surgical interventions. Clinical parameters and inflammatory markers, such as C-reactive protein (CRP) and leukocyte count, have been increasingly used to monitor patients, providing healthcare professionals with valuable information for diagnosing and stratifying. This study aimed to evaluate the association between CRP and leukocyte levels with infection severity, length of hospital stay, and treatment effectiveness in patients with odontogenic infections.</p> Materials and Methods <p>This cross-sectional study included a sample of 133 patients with odontogenic infections treated at Teresina Emergency Hospital between 2019 and 2023. Clinical data, including CRP and leukocyte levels, were obtained from medical records. Additional information, such as the number of involved fascial spaces, infection site location, need for surgical reoperation, and presence of dysphagia and/or dyspnea, was recorded in a standardized spreadsheet.</p> Results <p>Patients with longer hospital stays presented with higher leukocyte and CRP levels at admission. Elevated CRP and leukocyte levels at admission were also observed in patients with involvement of multiple fascial spaces, those requiring surgical reoperations, those reporting dysphagia and/or dyspnea, and those with mandibular infection. A statistically significant reduction in both CRP and leukocyte levels was observed from admission to hospital discharge.</p> Conclusions <p>Monitoring CRP and leukocyte levels is essential for tracking the progression of odontogenic infections. Higher levels at admission are associated with increased infection severity and longer hospital stays. These markers are expected to decrease by the time of discharge, reflecting the effectiveness of treatment.</p>