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Objectives <p>The C-reactive protein level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio provide essential information about postoperative inflammatory responses. This study aimed to establish normative ranges for the perioperative C-reactive protein level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio for orthognathic surgery by evaluating perioperative changes and influencing factors to identify postoperative complications earlier.</p> Materials and Methods <p>This prospective, self-controlled study included 60 patients who underwent orthognathic surgery with or without genioplasty. Patients were grouped into the single-jaw (SJ; n = 14) or double-jaw (DJ; n = 46) group. Preoperative (T0) and postoperative (T1: 1st day and T2: 2nd day) vital signs, visual analog scale scores, hemograms, and C-reactive protein values were analyzed.</p> Results <p>The mean T1 C-reactive protein level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio values were 52.41 ± 15.83&#xa0;mg/L, 7.67 ± 4.41, and 1.62 ± 0.74, respectively, for the SJ group, and 53.06 ± 22.72&#xa0;mg/L, 4.96 ± 1.42, and 2.09 ± 0.98, respectively, for the DJ group. The mean T2 C-reactive protein level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio values for the DJ group were 53.06 ± 22.72&#xa0;mg/L, 4.96 ± 1.42, and 2.09 ± 0.98, respectively. The DJ group demonstrated more significant inflammatory responses than the SJ group (<i>p</i> &lt; 0.05).</p> Conclusion <p>This study provides normative preoperative and postoperative ranges for the C-reactive protein level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio following orthognathic surgery, which are crucial for detecting postoperative complications.</p>

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Establishing Normative Ranges for C-reactive Protein, Neutrophil-to-Lymphocyte Ratio, and Lymphocyte-to-Monocyte Ratio for Orthognathic Surgery: A Prospective Study

  • 期刊论文

  • 发表日期：

    2025年9月21日

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  • Kıvanç Berke Ak,
  • Muazzez Süzen,
  • Selen Taylan,
  • Sina Uçkan

摘要

Objectives

The C-reactive protein level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio provide essential information about postoperative inflammatory responses. This study aimed to establish normative ranges for the perioperative C-reactive protein level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio for orthognathic surgery by evaluating perioperative changes and influencing factors to identify postoperative complications earlier.

Materials and Methods

This prospective, self-controlled study included 60 patients who underwent orthognathic surgery with or without genioplasty. Patients were grouped into the single-jaw (SJ; n = 14) or double-jaw (DJ; n = 46) group. Preoperative (T0) and postoperative (T1: 1st day and T2: 2nd day) vital signs, visual analog scale scores, hemograms, and C-reactive protein values were analyzed.

Results

The mean T1 C-reactive protein level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio values were 52.41 ± 15.83 mg/L, 7.67 ± 4.41, and 1.62 ± 0.74, respectively, for the SJ group, and 53.06 ± 22.72 mg/L, 4.96 ± 1.42, and 2.09 ± 0.98, respectively, for the DJ group. The mean T2 C-reactive protein level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio values for the DJ group were 53.06 ± 22.72 mg/L, 4.96 ± 1.42, and 2.09 ± 0.98, respectively. The DJ group demonstrated more significant inflammatory responses than the SJ group (p < 0.05).

Conclusion

This study provides normative preoperative and postoperative ranges for the C-reactive protein level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio following orthognathic surgery, which are crucial for detecting postoperative complications.