Scholarlink

Background <p>In recent times, autologous platelet concentrates (APCs) like platelet-rich fibrin (PRF) and platelet-rich fibrin matrix (PRFM) are utilized broadly to promote soft and hard tissue regeneration. The aim of the study was to evaluate PRF and PRFM in terms of pH changes (over a five-day period), antimicrobial potential and histological presentation using light microscopy and field-emission scanning electron microscopic analysis (FESEM).</p> Materials and Methods <p>A prospective comparative in vitro study was conducted in which PRF and PRFM samples were prepared from 21 healthy volunteers and a comparative evaluation for the parameters was carried out.</p> Results <p>A statistically significant difference was found between PRF and PRFM in terms of pH over a five-day period; antimicrobial efficacy at 48&#xa0;h; average thickness of fibrin; distribution of platelets and leucocytes entrapped in fibrin matrix.</p> Conclusion <p>From our research study, it can be concluded that PRF when compared to PRFM showed abundant entrapment of platelets and leucocytes enmeshed in the 3-D fibrin matrix which is responsible for its better antimicrobial property. PRF also showed increasing acidity over days which accelerates the process of wound healing at the injury site. Thus, PRF is a better autologous platelet concentrate than PRFM.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A Comparative Evaluation of Platelet-Rich Fibrin and Platelet-Rich Fibrin Matrix in Terms of pH, Antimicrobial Potential and Histological Presentation: An In vitro Study

  • 期刊论文

  • 发表日期：

    2025年6月4日

查看全文
  • Jasmine,
  • Hemant Batra,
  • Vandana Chhabra,
  • Anubha Gulati,
  • Sonia B. Bhardwaj

摘要

Background

In recent times, autologous platelet concentrates (APCs) like platelet-rich fibrin (PRF) and platelet-rich fibrin matrix (PRFM) are utilized broadly to promote soft and hard tissue regeneration. The aim of the study was to evaluate PRF and PRFM in terms of pH changes (over a five-day period), antimicrobial potential and histological presentation using light microscopy and field-emission scanning electron microscopic analysis (FESEM).

Materials and Methods

A prospective comparative in vitro study was conducted in which PRF and PRFM samples were prepared from 21 healthy volunteers and a comparative evaluation for the parameters was carried out.

Results

A statistically significant difference was found between PRF and PRFM in terms of pH over a five-day period; antimicrobial efficacy at 48 h; average thickness of fibrin; distribution of platelets and leucocytes entrapped in fibrin matrix.

Conclusion

From our research study, it can be concluded that PRF when compared to PRFM showed abundant entrapment of platelets and leucocytes enmeshed in the 3-D fibrin matrix which is responsible for its better antimicrobial property. PRF also showed increasing acidity over days which accelerates the process of wound healing at the injury site. Thus, PRF is a better autologous platelet concentrate than PRFM.