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Background <p>Renal clear cell carcinoma (RCCC) is the most common subtype of Renal cell carcinoma (RCC) originating from renal tubular epithelium and metastasis to the mandible is a rare occurrence, particularly in elderly patients and often indicates advanced disease.</p> Case Presentation <p>An 80-year-old female patient presenting with intraosseous lesion in the left mandibular body with clinical examination revealing a exophytic smooth growth with definite volumetric increase and soft tissue consistency. Histological studies indicated a diagnosis of clear cell carcinoma and metastatic lesion originating from left kidney was confirmed following contrast enhanced imaging studies with F18-FDG PET Scan of whole body. Patient has been put on targeted molecular therapy and is currently undergoing treatment.</p> Conclusion <p>Mandibular metastasis from RCCC is uncommon. This case highlights the importance of considering metastatic disease in elderly patients presenting with new oral lesions, even with a remote history of primary malignancy.</p>

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Exploring Rare Metastasis: Renal Clear Cell Carcinoma Presenting in the Mandible—A Case Report

  • 期刊论文

  • 发表日期：

    2025年5月22日

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  • Monika Parmar,
  • Vishakha Sharma,
  • Saransh Guleria,
  • Likshandeep Singh,
  • Anupriya Sharma

摘要

Background

Renal clear cell carcinoma (RCCC) is the most common subtype of Renal cell carcinoma (RCC) originating from renal tubular epithelium and metastasis to the mandible is a rare occurrence, particularly in elderly patients and often indicates advanced disease.

Case Presentation

An 80-year-old female patient presenting with intraosseous lesion in the left mandibular body with clinical examination revealing a exophytic smooth growth with definite volumetric increase and soft tissue consistency. Histological studies indicated a diagnosis of clear cell carcinoma and metastatic lesion originating from left kidney was confirmed following contrast enhanced imaging studies with F18-FDG PET Scan of whole body. Patient has been put on targeted molecular therapy and is currently undergoing treatment.

Conclusion

Mandibular metastasis from RCCC is uncommon. This case highlights the importance of considering metastatic disease in elderly patients presenting with new oral lesions, even with a remote history of primary malignancy.