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Introduction <p>The aim of this study was to evaluate the usefulness of periosteal flap in surgical treatment of stage-1 and stage-2 krokodil drug-related osteonecrosis of the mandible for decreasing the rate of disease recurrence.</p> Materials and Methods <p>Retrospective study of patients with stage-2 krokodil drug-related ON of the mandible was performed. In all patients, surgery was performed a minimum of 1&#xa0;month after drug cessation. Surgery in all cases included removal of necrotic bone and tension-free closure of the formed mandibular bone wound with local mucoperiosteal flaps and periosteal flap.</p> Results <p>12 patients were included in this study. In all patients the postoperative period was uneventful and no recurrence occurred.</p> Conclusion <p>Within the limitations of the study, radical debridement of necrotic bone and double–layer closure of the wound with periosteal flap can be used as an effective and predictable method for the treatment of mandible osteonecrosis due to krokodil drug use.</p>

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Double-Layer Closure of the Wound with Periosteal Flap in Surgical Treatment of Krokodil Drug–Related Osteonecrosis of Mandible (Case Series)

  • 期刊论文

  • 发表日期：

    2025年3月4日

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  • Koryun Hakobyan,
  • Yuri Poghosyan,
  • Aram Kasyan

摘要

Introduction

The aim of this study was to evaluate the usefulness of periosteal flap in surgical treatment of stage-1 and stage-2 krokodil drug-related osteonecrosis of the mandible for decreasing the rate of disease recurrence.

Materials and Methods

Retrospective study of patients with stage-2 krokodil drug-related ON of the mandible was performed. In all patients, surgery was performed a minimum of 1 month after drug cessation. Surgery in all cases included removal of necrotic bone and tension-free closure of the formed mandibular bone wound with local mucoperiosteal flaps and periosteal flap.

Results

12 patients were included in this study. In all patients the postoperative period was uneventful and no recurrence occurred.

Conclusion

Within the limitations of the study, radical debridement of necrotic bone and double–layer closure of the wound with periosteal flap can be used as an effective and predictable method for the treatment of mandible osteonecrosis due to krokodil drug use.