Odd Ball Paradigms of Rhino Facial Swellings: A Diagnostic Dilemma of Primary Subcutaneous Non-Hodgkin Lymphomas

Almost 14% of all head and neck malignancies are contributed by Lymphomas which are solid tumours of the immune system. Non-Hodgkin lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating in B-, T-, or natural killer T-cells with wide range of histological and clinical features, which can make diagnosis difficult. A 58-year-old male patient presented with a two-month history of swelling in the left cheek which was gradually progressing. Clinico radiological examinations were contradictory to each other with multiple differential diagnosis. Biopsy came out as primary subcutaneous NHL, which was neither clinically nor radiologically anticipated. This article is an attempt to address the diagnostic difficulty of odd clinical presentation such as rhino-facial swelling and to discuss the differential diagnosis of rhino-facial swellings. Typically, a multimodal approach is employed, and the principal ancillary technique that have been found to be useful in classification is IHC.