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<p>This research investigates chitin extraction from squid (<i>Sepioteuthis lessoniana</i>) gladius, conversion to chitosan (CH), and synthesizing N-succinyl chitosan (NSC) gel for biomedical applications. Structural analysis using UV, fluorescence, Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (<sup>1</sup>H-NMR), dynamic light scattering (DLS), and zeta potential confirmed successful NSC synthesis. The gel exhibited strong hemostatic activity, reducing clotting time to 60&#xa0;s, and showed good hemocompatibility (non-hemolytic at 20–100&#xa0;µg/mL). It demonstrated notable anti-inflammatory (∼ 85% at 1000&#xa0;µg/mL) and antioxidant (∼ 62% DPPH inhibition at 100&#xa0;µg/mL) properties. The gel effectively inhibited <i>Escherichia coli</i> (<i>E. coli</i>) (20 ± 0.7&#xa0;mm) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>) (19 ± 0.7&#xa0;mm). The zebrafish embryo (ZFE) assays indicated biocompatible up to 25&#xa0;µg/mL with minor abnormalities at ≥ 30&#xa0;µg/mL, indicating dose-dependent response. Overall, the NSC gel shows promise as a safe, multifunctional biomaterial for wound healing, infection control, and inflammation management, warranting further in vivo validation. This gel also holds strong potential for commercial development in wound care and topical therapeutic formulations.</p>

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N-Succinyl Chitosan Gel: Synthesis, Physicochemical Characterization, and Toxicological Evaluation for Biomedical Applications

  • 期刊论文

  • 发表日期：

    2025年10月25日

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  • Pavithra Amuthan Jayanthi,
  • Madhumitha Vijayanand,
  • Lekshmi Priya Anil Reena,
  • Kirtana Premnath,
  • Geethalakshmi Sundararaman,
  • Srinivasan Palaniselvam,
  • Saravanan Ramachandran

摘要

This research investigates chitin extraction from squid (Sepioteuthis lessoniana) gladius, conversion to chitosan (CH), and synthesizing N-succinyl chitosan (NSC) gel for biomedical applications. Structural analysis using UV, fluorescence, Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), dynamic light scattering (DLS), and zeta potential confirmed successful NSC synthesis. The gel exhibited strong hemostatic activity, reducing clotting time to 60 s, and showed good hemocompatibility (non-hemolytic at 20–100 µg/mL). It demonstrated notable anti-inflammatory (∼ 85% at 1000 µg/mL) and antioxidant (∼ 62% DPPH inhibition at 100 µg/mL) properties. The gel effectively inhibited Escherichia coli (E. coli) (20 ± 0.7 mm) and Staphylococcus aureus (S. aureus) (19 ± 0.7 mm). The zebrafish embryo (ZFE) assays indicated biocompatible up to 25 µg/mL with minor abnormalities at ≥ 30 µg/mL, indicating dose-dependent response. Overall, the NSC gel shows promise as a safe, multifunctional biomaterial for wound healing, infection control, and inflammation management, warranting further in vivo validation. This gel also holds strong potential for commercial development in wound care and topical therapeutic formulations.