Scholarlink

<p>The development of new insecticides for vector control is essential, particularly those employing multiple mechanisms of action. While insecticide use is necessary, it is crucial to address environmental impacts and the growing resistance of mosquitoes to synthetic products. Agro-industrial residues with biological activity offer a promising, eco-friendly alternative for insect control. This study aimed to produce and chemically characterize NatCNSL fractions, evaluate their insecticidal activity, elucidate toxicity mechanisms, and assess their environmental safety, particularly focusing on the fraction neutralized with 50% NaOH (NatCNSL50) formulation as a multifunctional biopesticide for <i>Ae. aegypti</i> control. Self-emulsifying systems were prepared through the partial and total neutralization of tCNSL with sodium hydroxide (NaOH) to enhance water solubility and biological activity. Larvicidal activity and histopathological effects of NatCNSL fractions on <i>Aedes aegypti</i> were evaluated through standard bioassays, while toxicity tests were conducted on non-target aquatic organisms (<i>Raphidocelis subcapitata</i>, <i>Daphnia similis</i>, and <i>Oreochromis niloticus</i>). Additionally, the mutagenic potential of NatCNSL50 was evaluated using the <i>Salmonella</i>/microsome assay. The fraction neutralized NatCNSL50 demonstrated potent larvicidal activity, targeting intestinal tissues of larvae, particularly the midgut and the midgut-hindgut transition, while exhibiting reduced toxicity to non-target organisms compared to WHO-recommended synthetic larvicides and no mutagenic or cytotoxic effects in the Salmonella/microsome assay. Cost-effective, scalable, and practical, NatCNSL50 aligns with Green Chemistry principles, offering a sustainable solution for large-scale domestic and urban vector control. This study highlights the potential of agro-industrial residues for developing eco-friendly insect control products, providing a foundation for future research on sustainable and environmentally conscious pest management solutions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Development of Sustainable Multifunctional Larvicides from Cashew Nut Shell Liquid (tCNSL) for Aedes aegypti Control

  • 期刊论文

  • 发表日期：

    2025年7月4日

查看全文
  • Bruno do Amaral Crispim,
  • Sabrina Rodrigues da Luz,
  • Felipe Mendes Merey,
  • Marina Stefanes Schibichewski,
  • Eduardo José de Arruda,
  • Diego Lomonaco,
  • Cláudio Rodrigo Nogueira,
  • Fabiana Gomes da Silva Dantas,
  • Kelly Mari Pires de Oliveira,
  • Bruno Fiorelini Pereira,
  • Alexeia Barufatti

摘要

The development of new insecticides for vector control is essential, particularly those employing multiple mechanisms of action. While insecticide use is necessary, it is crucial to address environmental impacts and the growing resistance of mosquitoes to synthetic products. Agro-industrial residues with biological activity offer a promising, eco-friendly alternative for insect control. This study aimed to produce and chemically characterize NatCNSL fractions, evaluate their insecticidal activity, elucidate toxicity mechanisms, and assess their environmental safety, particularly focusing on the fraction neutralized with 50% NaOH (NatCNSL50) formulation as a multifunctional biopesticide for Ae. aegypti control. Self-emulsifying systems were prepared through the partial and total neutralization of tCNSL with sodium hydroxide (NaOH) to enhance water solubility and biological activity. Larvicidal activity and histopathological effects of NatCNSL fractions on Aedes aegypti were evaluated through standard bioassays, while toxicity tests were conducted on non-target aquatic organisms (Raphidocelis subcapitata, Daphnia similis, and Oreochromis niloticus). Additionally, the mutagenic potential of NatCNSL50 was evaluated using the Salmonella/microsome assay. The fraction neutralized NatCNSL50 demonstrated potent larvicidal activity, targeting intestinal tissues of larvae, particularly the midgut and the midgut-hindgut transition, while exhibiting reduced toxicity to non-target organisms compared to WHO-recommended synthetic larvicides and no mutagenic or cytotoxic effects in the Salmonella/microsome assay. Cost-effective, scalable, and practical, NatCNSL50 aligns with Green Chemistry principles, offering a sustainable solution for large-scale domestic and urban vector control. This study highlights the potential of agro-industrial residues for developing eco-friendly insect control products, providing a foundation for future research on sustainable and environmentally conscious pest management solutions.