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<p>This research investigates the synthesis of bimetallic cobalt-nickel nanoparticles (Co-Ni NPs) using <i>Borassus flabellifer</i> (Toddy palm) extract and evaluates their antibacterial, antioxidant and anticancer properties. The Co-Ni NPs were characterized by X-ray diffraction (XRD), UV-Visible spectroscopy and electron microscopy. XRD analysis has revealed face-centred cubic Co-Ni NPs, having 16.82&#xa0;nm crystalline size. UV-Visible spectroscopy revealed a surface plasmon resonance peak at 367.96&#xa0;nm, indicating successful NPs formation. Electron microscopy (SEM and TEM) identified spherical NP with an average diameter of 12&#xa0;nm. Co-Ni NPs demonstrated significant antibacterial activity, with inhibition zones of 17&#xa0;mm, 15&#xa0;mm and 20&#xa0;mm against <i>E. coli</i>, <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>, respectively. In antioxidant assays, the Co-Ni NPs exhibited 82% Hydrogen peroxide radical scavenging activity, surpassing the standard antioxidant butylated hydroxytoluene (BHT), which showed 74% activity. Furthermore, the Co-Ni NPs displayed considerable anticancer activity, reducing cell viability by 65% in MDA-MB231 cells and 58% in SKOV-3 cells. These findings highlight the multifunctional potential of Co-Ni NPs synthesized through a green approach, suggesting their applications in antimicrobial, antioxidant and anticancer therapies. Further research is needed to optimize their efficacy and explore therapeutic applications.</p>

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Biogenic Co-Ni NPs Mediated by Toddy Palm: A Potent Antibacterial, Antioxidant and Anticancer Tool

  • 期刊论文

  • 发表日期：

    2025年6月2日

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  • Rani Padmini Velamakanni,
  • Aayasha Negi,
  • Dasa Karunakar,
  • Vagdevi Pally,
  • Rani Samyuktha Velamakanni,
  • Suman Bandari,
  • Ramchander Merugu

摘要

This research investigates the synthesis of bimetallic cobalt-nickel nanoparticles (Co-Ni NPs) using Borassus flabellifer (Toddy palm) extract and evaluates their antibacterial, antioxidant and anticancer properties. The Co-Ni NPs were characterized by X-ray diffraction (XRD), UV-Visible spectroscopy and electron microscopy. XRD analysis has revealed face-centred cubic Co-Ni NPs, having 16.82 nm crystalline size. UV-Visible spectroscopy revealed a surface plasmon resonance peak at 367.96 nm, indicating successful NPs formation. Electron microscopy (SEM and TEM) identified spherical NP with an average diameter of 12 nm. Co-Ni NPs demonstrated significant antibacterial activity, with inhibition zones of 17 mm, 15 mm and 20 mm against E. coli, Staphylococcus aureus and Pseudomonas aeruginosa, respectively. In antioxidant assays, the Co-Ni NPs exhibited 82% Hydrogen peroxide radical scavenging activity, surpassing the standard antioxidant butylated hydroxytoluene (BHT), which showed 74% activity. Furthermore, the Co-Ni NPs displayed considerable anticancer activity, reducing cell viability by 65% in MDA-MB231 cells and 58% in SKOV-3 cells. These findings highlight the multifunctional potential of Co-Ni NPs synthesized through a green approach, suggesting their applications in antimicrobial, antioxidant and anticancer therapies. Further research is needed to optimize their efficacy and explore therapeutic applications.