Scholarlink

<p>Exploring efficient sustainable approaches for the noble metal nanoparticles (NPs) synthesis has become a recent research attention. Bioreduction with actinobacteria provides a sustainable route for metal NPs synthesis, especially for noble metals. In this study, Palladium nanoparticles (Pd NPs) and a Palladium-reduced graphene oxide nanocomposite (rGO-Pd) were synthesized using <i>Streptomyces maritimus</i>, which acted as a reducing, capping, and stabilizing agent. The nanocomposite was evaluated for antimicrobial, antioxidant, and anticancer properties against MCF-7 human breast cancer cells. The synthesised Pd NPs and rGO-Pd nanocomposite were characterized through Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Dynamic light scattering (DLS), Atomic force microscopy (AFM), Scanning electron microscopy (SEM) and High-resolution Transmission electron microscopy (HR-TEM) analyses. FT-IR analysis revealed the role of various functional groups present in actinobacterial metabolites in formation of Pd NPs and rGO-Pd nanocomposite. The XRD analysis confirmed the Pd NPs and rGO-Pd nanocomposite are crystalline in nature with average crystalline size of 2.48&#xa0;nm and 11.37&#xa0;nm, respectively. However, SEM-EDX, AFM and HR-TEM analysis reveals the uniform morphology of nanocomposites with the average particle size of 12&#xa0;nm. The antibacterial efficacy of Pd NPs and rGO-Pd nanocomposite against <i>Enterococcus</i> sp, <i>Staphylococcus aures</i>, <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i> exhibited inhibition at 50&#xa0;µg/mL. In addition, rGO-Pd nanocomposite exhibited the inhibition on DPPH radicals with 80% scavenging activity, and rGO-Pd demonstrated anticancer activity with an IC<sub>50</sub> of 58.45&#xa0;µg/mL, respectively. This study suggests that <i>Streptomyces maritimus</i> mediated Pd NPs can effectively used as a potential therapeutic agent.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Fabrication of Palladium Nanoparticles and rGO-Pd Nanocomposite by Streptomyces maritimus: Antimicrobial, Antioxidant, and Scalable Applications

  • 期刊论文

  • 发表日期：

    2025年1月8日

查看全文
  • Mohanam Nithyalakshmi,
  • Nagarajan Siddharthan,
  • Elumalai Lokesh,
  • Mohammad Ahmad Wadaan,
  • Saurav Dixit,
  • Ramasamy Balagurunathan

摘要

Exploring efficient sustainable approaches for the noble metal nanoparticles (NPs) synthesis has become a recent research attention. Bioreduction with actinobacteria provides a sustainable route for metal NPs synthesis, especially for noble metals. In this study, Palladium nanoparticles (Pd NPs) and a Palladium-reduced graphene oxide nanocomposite (rGO-Pd) were synthesized using Streptomyces maritimus, which acted as a reducing, capping, and stabilizing agent. The nanocomposite was evaluated for antimicrobial, antioxidant, and anticancer properties against MCF-7 human breast cancer cells. The synthesised Pd NPs and rGO-Pd nanocomposite were characterized through Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Dynamic light scattering (DLS), Atomic force microscopy (AFM), Scanning electron microscopy (SEM) and High-resolution Transmission electron microscopy (HR-TEM) analyses. FT-IR analysis revealed the role of various functional groups present in actinobacterial metabolites in formation of Pd NPs and rGO-Pd nanocomposite. The XRD analysis confirmed the Pd NPs and rGO-Pd nanocomposite are crystalline in nature with average crystalline size of 2.48 nm and 11.37 nm, respectively. However, SEM-EDX, AFM and HR-TEM analysis reveals the uniform morphology of nanocomposites with the average particle size of 12 nm. The antibacterial efficacy of Pd NPs and rGO-Pd nanocomposite against Enterococcus sp, Staphylococcus aures, Klebsiella pneumoniae and Escherichia coli exhibited inhibition at 50 µg/mL. In addition, rGO-Pd nanocomposite exhibited the inhibition on DPPH radicals with 80% scavenging activity, and rGO-Pd demonstrated anticancer activity with an IC50 of 58.45 µg/mL, respectively. This study suggests that Streptomyces maritimus mediated Pd NPs can effectively used as a potential therapeutic agent.

Graphical Abstract