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<p>Trichinellosis, a serious zoonotic disease with significant impacts on human health, still faces various obstacles in its treatment. This is mainly due to the resistance of encysted larvae to the conventional antiparasitic drugs and the systemic inflammatory nature of the disease. <i>Moringa oleifera</i> has antiparasitic, anti-inflammatory, antioxidant and immunomodulatory potentials. Thus, the current study aimed to assess the efficacy of <i>Moringa oleifera</i> aqueous extract either alone or combined with albendazole on <i>Trichinella spiralis</i> experimentally infected mice. The study was conducted on 80 mice divided into five groups (16 mice each): healthy control, infected control, infected albendazole-treated, infected <i>Moringa oleifera</i> treated, and infected combined albendazole and <i>Moringa oleifera</i>-treated. Each group was further subdivided equally into 2 subgroups (a and b) with subgroup “a” representing the intestinal phase and subgroup “b” representing the muscular phase. Assessment was performed via parasitological, histopathological, immunohistochemical and biochemical studies. The results showed that <i>Moringa oleifera</i> amplified the antiparasitic effect of albendazole, inducing the maximum reduction in both adult and larval counts. This combination exhibited a strong anti-inflammatory effect, demonstrated by significant reduction of the elevated interleukin-6 and tumor necrosis factor-α levels, restoring normal cyclooxygenase-2 expression in the small intestine, reversal of the histopathological sequelae of infection and normalizing the histopathological score of both intestinal and muscle pathology. <i>Moringa</i> exerted <i>a</i> significant antiangiogenic effect, especially when combined with albendazole, restoring the strongly expressed vascular endothelial growth factor back to its normal expression in muscles. Combined treatment overcame the infection-induced oxidative stress and regained the normal redox status balance. Therefore, a combined regimen of <i>Moringa oleifera</i> aqueous extract and albendazole could be a promising treatment for trichinellosis.</p>

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Evaluation of the potential beneficial effects of Moringa oleifera on experimental Trichinella spiralis infection

  • 期刊论文

  • 发表日期：

    2026年5月30日

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  • Amina M. Salama,
  • Dina I. Elgendy,
  • Mahmoud S. Sharaf,
  • Heba M. Shoeib,
  • Mona M. Elwan,
  • Wesam M. A. Elgendy

摘要

Trichinellosis, a serious zoonotic disease with significant impacts on human health, still faces various obstacles in its treatment. This is mainly due to the resistance of encysted larvae to the conventional antiparasitic drugs and the systemic inflammatory nature of the disease. Moringa oleifera has antiparasitic, anti-inflammatory, antioxidant and immunomodulatory potentials. Thus, the current study aimed to assess the efficacy of Moringa oleifera aqueous extract either alone or combined with albendazole on Trichinella spiralis experimentally infected mice. The study was conducted on 80 mice divided into five groups (16 mice each): healthy control, infected control, infected albendazole-treated, infected Moringa oleifera treated, and infected combined albendazole and Moringa oleifera-treated. Each group was further subdivided equally into 2 subgroups (a and b) with subgroup “a” representing the intestinal phase and subgroup “b” representing the muscular phase. Assessment was performed via parasitological, histopathological, immunohistochemical and biochemical studies. The results showed that Moringa oleifera amplified the antiparasitic effect of albendazole, inducing the maximum reduction in both adult and larval counts. This combination exhibited a strong anti-inflammatory effect, demonstrated by significant reduction of the elevated interleukin-6 and tumor necrosis factor-α levels, restoring normal cyclooxygenase-2 expression in the small intestine, reversal of the histopathological sequelae of infection and normalizing the histopathological score of both intestinal and muscle pathology. Moringa exerted a significant antiangiogenic effect, especially when combined with albendazole, restoring the strongly expressed vascular endothelial growth factor back to its normal expression in muscles. Combined treatment overcame the infection-induced oxidative stress and regained the normal redox status balance. Therefore, a combined regimen of Moringa oleifera aqueous extract and albendazole could be a promising treatment for trichinellosis.