Scholarlink

<p><i>Cryptosporidium</i> spp. are opportunistic pathogens that can cause severe gastrointestinal illness, particularly in immunocompromised individuals such as those with HIV/AIDS. In this study, we aimed to determine the prevalence of <i>Cryptosporidium parvum</i> among HIV-positive individuals. One hundred HIV-positive patients were recruited from the Behavior Disease Consultation Center of Rajai Hospital, Tabriz, Iran. Stool and serum samples were collected for microscopic and serological identification of Cryptosporidiosis. Statistical analysis was conducted with SPSS version 23. Parasites were detected in 14 (14%) of the 100 stool specimens submitted for ova and parasite examination. Twenty-three (23%) of the 100 subjects had positive titers (4 were females, 19 were males). There was no statistically significant correlation between the subset of the study population with anticryptosporidial IgG and sexual behaviour and intravenous drug users (<i>P</i>-value &gt; 0.05). A statistically significant was found between anticryptosporidial IgG and CD4 count (<i>P</i>-value &lt; 0.0001). The results further demonstrated that among the 45 Antiretroviral Therapy (ART) responders, <i>C. parvum</i> IgG antibodies were detected in 5 patients (11.1%), while stool examination was positive in 2 patients (4.4%). In contrast, among the 55 ART non-responders, IgG antibodies were detected in 18 patients (32.7%), and stool examination was positive in 12 patients (21.8%). Overall, the prevalence of both seropositivity and stool positivity was significantly higher in ART non-responders compared to responders (<i>P</i> &lt; 0.05). These findings highlight the importance of routine screening for <i>Cryptosporidium</i> in HIV-positive patients to inform clinical management strategies and prevent disease transmission.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Investigation of the prevalence of Cryptosporidium parvum among HIV-positive individuals with recombinant CP2 and CP23 antigens

  • 期刊论文

  • 发表日期：

    2026年2月20日

查看全文
  • Majid Dousti,
  • Ahmed M. Amshawee,
  • Melad Ahmed Al-Saeed,
  • Inam Al-Mamorri,
  • Yusra Hardan Jasim,
  • Maryam A. Hussain,
  • Maryam Nasiri,
  • Fatemeh Sadat Seyedi Asl,
  • Gholamreza Barezgar

摘要

Cryptosporidium spp. are opportunistic pathogens that can cause severe gastrointestinal illness, particularly in immunocompromised individuals such as those with HIV/AIDS. In this study, we aimed to determine the prevalence of Cryptosporidium parvum among HIV-positive individuals. One hundred HIV-positive patients were recruited from the Behavior Disease Consultation Center of Rajai Hospital, Tabriz, Iran. Stool and serum samples were collected for microscopic and serological identification of Cryptosporidiosis. Statistical analysis was conducted with SPSS version 23. Parasites were detected in 14 (14%) of the 100 stool specimens submitted for ova and parasite examination. Twenty-three (23%) of the 100 subjects had positive titers (4 were females, 19 were males). There was no statistically significant correlation between the subset of the study population with anticryptosporidial IgG and sexual behaviour and intravenous drug users (P-value > 0.05). A statistically significant was found between anticryptosporidial IgG and CD4 count (P-value < 0.0001). The results further demonstrated that among the 45 Antiretroviral Therapy (ART) responders, C. parvum IgG antibodies were detected in 5 patients (11.1%), while stool examination was positive in 2 patients (4.4%). In contrast, among the 55 ART non-responders, IgG antibodies were detected in 18 patients (32.7%), and stool examination was positive in 12 patients (21.8%). Overall, the prevalence of both seropositivity and stool positivity was significantly higher in ART non-responders compared to responders (P < 0.05). These findings highlight the importance of routine screening for Cryptosporidium in HIV-positive patients to inform clinical management strategies and prevent disease transmission.