<p><i>Anisakis typica</i> is a zoonotic nematode parasite of fish. The unique transfer of anisakines from ‘dolphin reservoir’ in the Gangetic riverine ecosystem via the estuarine buffer zone in the Bay of Bengal, across a salinity gradient to the richer coral reef-diversity areas of Grande Island, India, in the Central west coast of India at Goa are reported in this investigation. After <i>Anisakis typica</i>’s occurrence record in Indian waters for the first time by the authors in 2024, the unique definitive and paratenic host status of this bioinvasive species is presented. The spillover of extracellular vesicles over the body surface of anisakine worms is also documented. This, therefore, triggered the need for self-generated specific resistance in the parasite to fight out nematode effectors in the altered marine environment. In conclusion, the unique linguiform papilla on cephalic complex and physalopteridae characteristics of sclerotized collarette at cephalic and post-caudal ends were the distinguishable features of first and second stage larvae from other <i>A. typica</i> recorded globally. Molecular analyses revealed alignment of <i>A. typica</i> harboured by fish in the marine ecosystem with those parasitizing Gangetic riverine pathways. Hence, this first unique discovery of adult worms as well as 3rd stage larvae together in the definitive host-fish in marine (<i>S. sihama</i>) as well as freshwaters (<i>Bagarius bagarius</i>) in India. Thus, in addition to human beings, the status of definitive host is assigned to <i>B. bagarius</i> and <i>S. sihama</i>, which also served as paratenic hosts under conditions of climate change while they traversed long stretches of streams from the river Ganges to the Arabian Sea.</p>