Scholarlink

<p>Canine Ehrlichiosis, caused by <i>Ehrlichia canis</i> and transmitted through the brown dog tick (<i>Rhipicephalus sanguineus</i>), poses a significant health challenge to dogs in India, where the warm climate favors tick proliferation. This study employs a meta-analytical approach to analyze the clinical and biochemical markers of Canine Monocytic Ehrlichiosis (CME) over the past decade (2014–2024) across India. The objective is to assess the diagnostic value of thrombocytopenia and elevated liver enzymes aspartate transaminase, alanine transaminase, and alkaline phosphatase (AST, ALT, ALP) in dogs affected by CME. Following PRISMA guidelines, 13 relevant studies were selected after screening 2,018 publications. Data were pooled to evaluate the associations between biochemical markers and CME. The meta-analysis found moderate associations between thrombocytopenia and CME (SMD = 0.34, I<sup>2</sup> = 94.5%) and stronger correlations with elevated liver enzymes: ALT (SMD = 2.47, I<sup>2</sup> = 94.0%), AST (SMD = 2.23, I<sup>2</sup> = 94.3%), and ALP (SMD = 2.31, I<sup>2</sup> = 91.9%). High heterogeneity among studies was noted, but the findings underscore the importance of these biochemical markers in CME diagnosis. Meta-influence analyses confirmed the robustness of the results, with no individual study disproportionately affecting the pooled estimates. Publication bias tests, including Egger’s and Begg’s, revealed no significant bias, ensuring the reliability of the conclusions. These findings highlight the critical role of liver enzyme evaluations in diagnosing CME, while thrombocytopenia remains a supplementary marker. This study contributes to a more standardized understanding of CME’s clinical diagnosis and emphasizes the need for further research to reduce variability in future studies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association of thrombocytopenia and liver enzymes in canine monocytic ehrlichiosis: a meta-analysis

  • 期刊论文

  • 发表日期：

    2025年5月22日

查看全文
  • Ashish Kumar,
  • Ambika Sharma,
  • Vikas Kumar,
  • Megha Agrawal,
  • Kalpana Tiwari,
  • Chahat Choudhary,
  • Gyan Vardhan

摘要

Canine Ehrlichiosis, caused by Ehrlichia canis and transmitted through the brown dog tick (Rhipicephalus sanguineus), poses a significant health challenge to dogs in India, where the warm climate favors tick proliferation. This study employs a meta-analytical approach to analyze the clinical and biochemical markers of Canine Monocytic Ehrlichiosis (CME) over the past decade (2014–2024) across India. The objective is to assess the diagnostic value of thrombocytopenia and elevated liver enzymes aspartate transaminase, alanine transaminase, and alkaline phosphatase (AST, ALT, ALP) in dogs affected by CME. Following PRISMA guidelines, 13 relevant studies were selected after screening 2,018 publications. Data were pooled to evaluate the associations between biochemical markers and CME. The meta-analysis found moderate associations between thrombocytopenia and CME (SMD = 0.34, I2 = 94.5%) and stronger correlations with elevated liver enzymes: ALT (SMD = 2.47, I2 = 94.0%), AST (SMD = 2.23, I2 = 94.3%), and ALP (SMD = 2.31, I2 = 91.9%). High heterogeneity among studies was noted, but the findings underscore the importance of these biochemical markers in CME diagnosis. Meta-influence analyses confirmed the robustness of the results, with no individual study disproportionately affecting the pooled estimates. Publication bias tests, including Egger’s and Begg’s, revealed no significant bias, ensuring the reliability of the conclusions. These findings highlight the critical role of liver enzyme evaluations in diagnosing CME, while thrombocytopenia remains a supplementary marker. This study contributes to a more standardized understanding of CME’s clinical diagnosis and emphasizes the need for further research to reduce variability in future studies.