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<p>Toxoplasmosis is a common protozoal disease that can cause serious complications. Hence the available drug therapies possess limited activity against chronic forms of the disease; thus, it is urgent to find more effective agents. The current study highlighted the therapeutic activity of bone marrow mesenchymal stem cells (BMSCs) and ginger combined with spiramycin against chronic experimental toxoplasmosis. A total of 48 male <i>Swiss albino</i> mice were distributed into 8 groups: non-infected non-treated, infected non-treated, infected treated by spiramycin, infected treated by BMSCs, infected treated by ginger, infected treated by combined BMSCs and spiramycin, infected treated by combined BMSCs and ginger, and infected treated by combined BMSCs, ginger, and spiramycin. The evaluation was performed through parasitological counting of brain cyst burden, histopathological examination, immunohistochemical cyclooxygenase-2 (COX-2) staining assessment, serum IL-10 measurement, and apoptotic gene markers assay. The results revealed that combined BMSCs, ginger, and spiramycin displayed significantly reduced parasitic cyst burden, restored histopathological changes, decreased COX2 expression, and downregulated caspases gene expression. It can be concluded that adding BMSCs and ginger to spiramycin provides a potent therapeutic agent against chronic toxoplasmosis.</p>

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Therapeutic outcome of bone marrow stem cells and ginger in chronic murine toxoplasmosis

  • 期刊论文

  • 发表日期：

    2025年5月17日

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  • Zeinab R. Hassan,
  • Yasmeen M. Shaaban,
  • Eman M. Mahmoud,
  • Amany Mesbah Mohammed Ali,
  • Fatma Al-Zahraa Nabil Al-shahed,
  • Doaa E. A. Salama,
  • Amira Nasr Ismail Elsokary,
  • Ranya M. Abdelgalil,
  • Marwa A. Alanany,
  • Mona T. Koullah,
  • Nora Seliem,
  • Doaa Refaat Amin,
  • Shimaa A. Mohamed,
  • Mai Ali Mohammad Etewa,
  • Sara Nagdy Mahmoud Mousa,
  • Mona M. Amin,
  • Maryam Mohammed Mohammed Hamouda,
  • Shimaa Attia Atta,
  • Reham abdelmonem Gadallah,
  • Sami Mohamed Nasr

摘要

Toxoplasmosis is a common protozoal disease that can cause serious complications. Hence the available drug therapies possess limited activity against chronic forms of the disease; thus, it is urgent to find more effective agents. The current study highlighted the therapeutic activity of bone marrow mesenchymal stem cells (BMSCs) and ginger combined with spiramycin against chronic experimental toxoplasmosis. A total of 48 male Swiss albino mice were distributed into 8 groups: non-infected non-treated, infected non-treated, infected treated by spiramycin, infected treated by BMSCs, infected treated by ginger, infected treated by combined BMSCs and spiramycin, infected treated by combined BMSCs and ginger, and infected treated by combined BMSCs, ginger, and spiramycin. The evaluation was performed through parasitological counting of brain cyst burden, histopathological examination, immunohistochemical cyclooxygenase-2 (COX-2) staining assessment, serum IL-10 measurement, and apoptotic gene markers assay. The results revealed that combined BMSCs, ginger, and spiramycin displayed significantly reduced parasitic cyst burden, restored histopathological changes, decreased COX2 expression, and downregulated caspases gene expression. It can be concluded that adding BMSCs and ginger to spiramycin provides a potent therapeutic agent against chronic toxoplasmosis.