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<p>Silica nanoparticles (NPs) are among the promising platforms for the delivery of a wide variety of drugs (either hydrophilic or hydrophobic drugs) especially hydrophobic low-soluble agents such as curcumin. Through using nanoplatforms, curcumin may become more bioavailable for more efficacy in the field of cancer therapy. Silica NPs with a wide span of applications, possessing mesoporous structure, namely mesoporous silica nanoparticles (MSNs) are widely manipulatable for this purpose. This review provides a comprehensive analysis of MSN-based drug delivery systems tailored for curcumin, focusing on (1) structural and functional engineering of MSNs to optimize loading efficiency and controlled release, (2) active targeting strategies (e.g., ligand conjugation) to improve tumor specificity, and (3) stimuli-responsive designs (pH-, redox-, or light-triggered systems) that enhance precision in diverse tumor microenvironments. We critically evaluate preclinical studies demonstrating how MSN-curcumin formulations amplify anticancer efficacy through synergistic modulation of apoptosis, angiogenesis, and metastasis pathways. The mechanisms of action in which curcumin asserts its effect on tumoral cells have also been presented by applying silica NPs. Furthermore, we discuss translational challenges and opportunities, emphasizing scalability, toxicity profiles, and combinatorial approaches with conventional therapies. This review establishes MSNs as a versatile and clinically promising strategy to unlock curcumin’s full potential in oncology.</p>

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Enhancing Cancer Therapy with Silica Nanoparticles: Exploring Curcumin-based Drug Delivery Systems

  • 期刊论文

  • 发表日期：

    2025年8月10日

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  • Niloufar Rahiman,
  • Prashant Kesharwani,
  • Tannaz Jamialahmadi,
  • Amirhossein Sahebkar

摘要

Silica nanoparticles (NPs) are among the promising platforms for the delivery of a wide variety of drugs (either hydrophilic or hydrophobic drugs) especially hydrophobic low-soluble agents such as curcumin. Through using nanoplatforms, curcumin may become more bioavailable for more efficacy in the field of cancer therapy. Silica NPs with a wide span of applications, possessing mesoporous structure, namely mesoporous silica nanoparticles (MSNs) are widely manipulatable for this purpose. This review provides a comprehensive analysis of MSN-based drug delivery systems tailored for curcumin, focusing on (1) structural and functional engineering of MSNs to optimize loading efficiency and controlled release, (2) active targeting strategies (e.g., ligand conjugation) to improve tumor specificity, and (3) stimuli-responsive designs (pH-, redox-, or light-triggered systems) that enhance precision in diverse tumor microenvironments. We critically evaluate preclinical studies demonstrating how MSN-curcumin formulations amplify anticancer efficacy through synergistic modulation of apoptosis, angiogenesis, and metastasis pathways. The mechanisms of action in which curcumin asserts its effect on tumoral cells have also been presented by applying silica NPs. Furthermore, we discuss translational challenges and opportunities, emphasizing scalability, toxicity profiles, and combinatorial approaches with conventional therapies. This review establishes MSNs as a versatile and clinically promising strategy to unlock curcumin’s full potential in oncology.