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<p>Postoperative cognitive dysfunction (POCD) is a frequent neuroinflammatory complication in elderly patients, and dexmedetomidine has shown potential in reducing its incidence by modulating the CX3CL1/CX3CR1 signaling pathway. In this study, carboxymethyl chitosan (CMCS) was chemically modified with a silicon-based polymer (CPTMS) and a natural extract (compound 2) to construct a functionalized carrier material, CPTMS-CMCS-2. This hybrid platform was subsequently loaded with compound 1 and dexamethasone (Dex), yielding the electroactive nanocomposite CPTMS-CMCS-2@1@Dex. Electrochemical characterization revealed that the incorporation of π-conjugated structures and bioactive components enhanced the redox activity, electron transfer efficiency, and surface conductivity of the material, which are beneficial for stimuli-responsive drug release. A POCD rat model was established via abdominal surgery, followed by cognitive assessment using the Morris water maze and analysis of hippocampal CX3CL1 mRNA expression. The results showed that intervention with CPTMS-CMCS-2@1@Dex significantly improved the spatial learning ability of POCD model rats. This study provides new insights into the pathogenesis of POCD and highlights the potential of electroactive, functionalized polysaccharide-based nanocarriers in enhancing the therapeutic efficacy of dexmedetomidine through responsive delivery systems.</p>

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Silicon-Modified Electrochemical Sensing and Drug Delivery Platform for Sensitive Dex Detection and Prevention of Postoperative Cognitive Dysfunction

  • 期刊论文

  • 发表日期：

    2025年7月30日

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  • Hongquan Ren,
  • Yuan Cao,
  • Minna Hou,
  • Jiao Guo

摘要

Postoperative cognitive dysfunction (POCD) is a frequent neuroinflammatory complication in elderly patients, and dexmedetomidine has shown potential in reducing its incidence by modulating the CX3CL1/CX3CR1 signaling pathway. In this study, carboxymethyl chitosan (CMCS) was chemically modified with a silicon-based polymer (CPTMS) and a natural extract (compound 2) to construct a functionalized carrier material, CPTMS-CMCS-2. This hybrid platform was subsequently loaded with compound 1 and dexamethasone (Dex), yielding the electroactive nanocomposite CPTMS-CMCS-2@1@Dex. Electrochemical characterization revealed that the incorporation of π-conjugated structures and bioactive components enhanced the redox activity, electron transfer efficiency, and surface conductivity of the material, which are beneficial for stimuli-responsive drug release. A POCD rat model was established via abdominal surgery, followed by cognitive assessment using the Morris water maze and analysis of hippocampal CX3CL1 mRNA expression. The results showed that intervention with CPTMS-CMCS-2@1@Dex significantly improved the spatial learning ability of POCD model rats. This study provides new insights into the pathogenesis of POCD and highlights the potential of electroactive, functionalized polysaccharide-based nanocarriers in enhancing the therapeutic efficacy of dexmedetomidine through responsive delivery systems.