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<p>Stroke, also known as cerebral apoplexy, is a severe cerebrovascular disease characterized by high incidence, high disability rates, and high mortality rates. It is caused by the sudden rupture or blockage of brain blood vessels, leading to insufficient blood flow and subsequent brain tissue damage. Chemokine ligand 4 (CCL4) is a pro-inflammatory mediator significantly upregulated after cerebral ischemia–reperfusion injury. It is secreted in large amounts by brain microvascular endothelial cells through autocrine mechanisms, thereby exacerbating inflammatory damage. In this study, we synthesized PDMS-CP1@Propofol and demonstrated its protective effects on brain microvascular endothelial cells by effectively alleviating CCL4-induced inflammation. CP1 was synthesized under solvothermal conditions as a novel coordination polymer (CP) containing Cu(II), [Cu(QDA)]·DMF (1, H<sub>2</sub>QDA = quinoline-2,6-dicarboxylic acid, DMF = N,N-dimethylformamide). Structural analysis revealed a PtS topology with a CuO<sub>4</sub>N distorted square pyramidal geometry, while molecular docking simulations showed that carboxyl oxygen atoms formed hydrogen bonds with Cu ions, whereas nitrogen atoms in quinoline rings coordinated with Cu ions without forming hydrogen bonds. These findings highlight the potential of PDMS-CP1@Propofol and Cu(II)-based coordination polymers as promising platforms for mitigating inflammatory responses and developing therapeutic strategies for stroke treatment.</p>

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Silicon-Based Composite Nanocarrier Material Enhancing AIE Sensing for Iron Ion Detection and Stroke Treatment

  • 期刊论文

  • 发表日期：

    2025年6月9日

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  • Dian Chen,
  • Yueyang Yu,
  • Jian Zhu

摘要

Stroke, also known as cerebral apoplexy, is a severe cerebrovascular disease characterized by high incidence, high disability rates, and high mortality rates. It is caused by the sudden rupture or blockage of brain blood vessels, leading to insufficient blood flow and subsequent brain tissue damage. Chemokine ligand 4 (CCL4) is a pro-inflammatory mediator significantly upregulated after cerebral ischemia–reperfusion injury. It is secreted in large amounts by brain microvascular endothelial cells through autocrine mechanisms, thereby exacerbating inflammatory damage. In this study, we synthesized PDMS-CP1@Propofol and demonstrated its protective effects on brain microvascular endothelial cells by effectively alleviating CCL4-induced inflammation. CP1 was synthesized under solvothermal conditions as a novel coordination polymer (CP) containing Cu(II), [Cu(QDA)]·DMF (1, H2QDA = quinoline-2,6-dicarboxylic acid, DMF = N,N-dimethylformamide). Structural analysis revealed a PtS topology with a CuO4N distorted square pyramidal geometry, while molecular docking simulations showed that carboxyl oxygen atoms formed hydrogen bonds with Cu ions, whereas nitrogen atoms in quinoline rings coordinated with Cu ions without forming hydrogen bonds. These findings highlight the potential of PDMS-CP1@Propofol and Cu(II)-based coordination polymers as promising platforms for mitigating inflammatory responses and developing therapeutic strategies for stroke treatment.