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Purpose of review <p>This review encompasses all aspects crucial to oncofertility care for breast cancer (BC) patients. This includes fertility preservation strategies, alternative family building options, and the impact of gonadotoxic treatments on fertility, maternal and fetal safety. It also highlights the impact of BC beyond pregnancy and childbirth, including lactation and parenthood.</p> Recent findings <p>A significant knowledge gap on well-established fertility preservation methods as well as access to these methods. For alternative family building options such as adoption and surrogacy, cost and legal regulations can be prohibitive. Recent studies on endocrine therapy interruption and newer agents such as antibody–drug conjugates, cyclin-dependent kinase 4/6 (CDK4/6) inhibitors and immune checkpoint inhibitors show promising data regarding safety and ovarian function. Studies on lactation after BC show that breastfeeding is still possible after breast-conserving surgery and radiation. Parenthood after BC can add financial and childcare burden while navigating cancer care.</p> Summary <p>Oncofertility counseling requires a multidisciplinary approach starting at diagnosis and extending years after completion of treatment. Patients and clinicians should be well informed on all aspects of oncofertility care to facilitate decision-making regarding family-building.</p>

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Pregnancy and Parenthood After Breast Cancer

  • 期刊论文

  • 发表日期：

    2025年6月30日

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  • MacKenzie Adams,
  • Ying Jie Lock,
  • Alexa Steckler,
  • Sheetal Kumar,
  • Don S. Dizon,
  • Christine M. Duffy,
  • Mary Anne Fenton,
  • May-Tal Sauerbrun-Cutler,
  • Stephanie L. Graff

摘要

Purpose of review

This review encompasses all aspects crucial to oncofertility care for breast cancer (BC) patients. This includes fertility preservation strategies, alternative family building options, and the impact of gonadotoxic treatments on fertility, maternal and fetal safety. It also highlights the impact of BC beyond pregnancy and childbirth, including lactation and parenthood.

Recent findings

A significant knowledge gap on well-established fertility preservation methods as well as access to these methods. For alternative family building options such as adoption and surrogacy, cost and legal regulations can be prohibitive. Recent studies on endocrine therapy interruption and newer agents such as antibody–drug conjugates, cyclin-dependent kinase 4/6 (CDK4/6) inhibitors and immune checkpoint inhibitors show promising data regarding safety and ovarian function. Studies on lactation after BC show that breastfeeding is still possible after breast-conserving surgery and radiation. Parenthood after BC can add financial and childcare burden while navigating cancer care.

Summary

Oncofertility counseling requires a multidisciplinary approach starting at diagnosis and extending years after completion of treatment. Patients and clinicians should be well informed on all aspects of oncofertility care to facilitate decision-making regarding family-building.