Radiotherapy in Triple Negative Breast Cancer – Current Standards and Future Directions

Triple negative breast cancer remains a diagnosis that strikes fear into patients and providers alike due to its associated treatment challenges and natural history. The recent decades have seen significant advances in the field of breast cancer radiation oncology, and in this review we seek to highlight current standards of care, the historic basis for current recommendations, and future directions.

Advances in the field of breast radiation oncology have been numerous in the recent decades and include various hypofractionated regimens, new data and nuances in the administration of regional nodal radiation, new systemic agents and combinations with radiotherapy, and novel strategies that radically change current treatment paradigms. In this review, we will navigate the applicability of these data and approaches to the management of triple negative breast cancer.

Triple negative breast cancer remains a challenging disease process, but one that we have seen considerable advancement in the management of in the recent decades. We are optimistic that patients will continue to benefit from treatment approaches that improve disease control and quality of life.