Upgrade Rate and Long-term Outcomes of Lobular Neoplasia

Lobular neoplasia is a risk factor for breast cancer development, but its management remains controversial as upgrade rates differ depending on the subtype. This review of the literature aims to identify upgrade rates of lobular neoplasia, including their variants, discuss predictors of upgrade to malignancy, and provide information on long-term outcomes.

Upgrade rates for atypical lobular hyperplasia and classic lobular carcinoma in situ are lower than non-classic lobular carcinoma in situ. Recent studies have focused on determining predictors of upgrade to malignancy with variable findings.

Upgrade rates for atypical lobular hyperplasia and classic lobular carcinoma in situ with concordant imaging-pathology remain low allowing for a surveillance approach. More studies on predictors of malignancy are needed to allow better counseling on management options for patients with these high-risk lesions.