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<p>The gut microbiota plays a crucial function in reproductive well-being and is vital for maintaining fundamental physiological balance. This article surveys the mutual relationships between the gut flora and the female reproductive system, which are maintained through metabolic, immunological, and neuroendocrine mechanisms, thereby creating the gastrointestinal-reproductive axis. Dysbiosis, which results from an imbalance in microbial levels, has been related with reproductive diseases, such as polycystic ovary syndrome (PCOS), infertility, endometriosis, and pregnancy-related problems. Modulation of the gut microbiota via targeted synthetic materials, such as metformin, dietary phytocompounds, synbiotics, probiotics, and prebiotics, affects hormonal levels, glucose resistance, and monthly cycle regulation, showcasing favorable prospects for medical care. This review elucidates the molecular and cellular processes underlying gut-reproductive relationships and assesses the potential of microbiome-targeted medications as viable clinical approaches for enhancing fertility outcomes. Further attention should be devoted to determining the crosstalk between endometrial disruption, hormonal imbalance, and inflammation.</p>

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Hormonal Imbalance and Gut Dysbiosis: Emerging Perspectives in Women’s Health

  • 期刊论文

  • 发表日期：

    2026年6月20日

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  • Rupayan De,
  • Sayan Chakrabortty,
  • Joy Das,
  • Priya Chaudhary,
  • Rupam Patra,
  • Kousik Sardar,
  • Rajarshi Nath,
  • Radheshyam Pal,
  • Biplab Debnath,
  • Sumel Ashique

摘要

The gut microbiota plays a crucial function in reproductive well-being and is vital for maintaining fundamental physiological balance. This article surveys the mutual relationships between the gut flora and the female reproductive system, which are maintained through metabolic, immunological, and neuroendocrine mechanisms, thereby creating the gastrointestinal-reproductive axis. Dysbiosis, which results from an imbalance in microbial levels, has been related with reproductive diseases, such as polycystic ovary syndrome (PCOS), infertility, endometriosis, and pregnancy-related problems. Modulation of the gut microbiota via targeted synthetic materials, such as metformin, dietary phytocompounds, synbiotics, probiotics, and prebiotics, affects hormonal levels, glucose resistance, and monthly cycle regulation, showcasing favorable prospects for medical care. This review elucidates the molecular and cellular processes underlying gut-reproductive relationships and assesses the potential of microbiome-targeted medications as viable clinical approaches for enhancing fertility outcomes. Further attention should be devoted to determining the crosstalk between endometrial disruption, hormonal imbalance, and inflammation.