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<p>This study comprehensively explored the probiotic and technological attributes, antimicrobial capabilities, safety, and anti-biofilm effects of the <i>Lactiplantibacillus plantarum</i> R2 strain. The strain exhibited robust resilience to gastrointestinal conditions and high colonization potential, characterized by a 13.37% adhesion rate to Caco-2 cells. Its cell-free supernatant (CFS) effectively reduced <i>Listeria monocytogenes</i> biofilm biomass, correlating with the significant downregulation of key virulence genes. Furthermore, the CFS demonstrated potent antioxidant activity (DPPH: 62.56%, ABTS: 65.23%) and notable antiproliferative (anticancer) effects against HT-29, HeLa, and MCF-7 cancer cell lines. Technologically, R2 was identified as a strong acidifier with significant proteolytic activity and high exopolysaccharide (EPS) production. Safety assays confirmed the absence of hemolytic activity, DNase production, and biogenic amine synthesis. In conclusion, <i>L. plantarum</i> R2 represents a multifunctional candidate for the development of targeted functional foods and biotherapeutic formulations aimed at modulating the intestinal microbiota and mitigating pathogen-induced enteric disorders.</p>

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Probiotic Potential, Safety, and Technological Attributes of Lactiplantibacillus plantarum R2: Potent Antibiofilm and Cytotoxic Efficacy

  • 期刊论文

  • 发表日期：

    2026年4月29日

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  • Parisa Ghasemi,
  • Behrooz Alizadeh Behbahani,
  • Mohammad Noshad,
  • Zahra Nikfarjam,
  • Alireza Vasiee

摘要

This study comprehensively explored the probiotic and technological attributes, antimicrobial capabilities, safety, and anti-biofilm effects of the Lactiplantibacillus plantarum R2 strain. The strain exhibited robust resilience to gastrointestinal conditions and high colonization potential, characterized by a 13.37% adhesion rate to Caco-2 cells. Its cell-free supernatant (CFS) effectively reduced Listeria monocytogenes biofilm biomass, correlating with the significant downregulation of key virulence genes. Furthermore, the CFS demonstrated potent antioxidant activity (DPPH: 62.56%, ABTS: 65.23%) and notable antiproliferative (anticancer) effects against HT-29, HeLa, and MCF-7 cancer cell lines. Technologically, R2 was identified as a strong acidifier with significant proteolytic activity and high exopolysaccharide (EPS) production. Safety assays confirmed the absence of hemolytic activity, DNase production, and biogenic amine synthesis. In conclusion, L. plantarum R2 represents a multifunctional candidate for the development of targeted functional foods and biotherapeutic formulations aimed at modulating the intestinal microbiota and mitigating pathogen-induced enteric disorders.