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Background <p><i>Helicobacter pylori</i> (<i>H. pylori</i>) is a common gastrointestinal pathogen that can persist for decades and lead to diseases like gastritis, peptic ulcers, and gastric cancer. Conventional antibiotic treatments have limitations like resistance and side effects, requiring alternative therapies. The gut microbiota may influence <i>H. pylori</i> colonization and eradication success.</p> Main Body of the abstract <p>Strategies like probiotics, prebiotics, diet, and lifestyle changes may modulate the gut microbiota composition and function to inhibit <i>H. pylori</i> growth. Specific probiotic strains produce antimicrobial compounds, modulate immune responses, and alter gut microbiota in ways that can promote <i>H. pylori</i> eradication. Diets high in fiber, polyphenols, omega-3s, and fermented foods appear to inhibit <i>H. pylori</i> by supporting growth of beneficial bacteria. Lifestyle factors like stress, smoking, and alcohol negatively impact the gut microbiota. Personalized therapies based on the gut microbiome could optimize eradication rates.</p> Conclusion <p>The gut microbiota represents a promising target for enhancing <i>H. pylori</i> eradication. Further research on microbiota-modulating therapies like probiotics, diet, and lifestyle changes may help develop more effective, personalized treatment approaches.</p>

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Probiotics and Diet Modifications: A Holistic Approach to Tackling Helicobacter pylori with the Help of the Gut Microbiota

  • 期刊论文

  • 发表日期：

    2025年8月12日

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  • Tamer A. Addissouky,
  • Yuliang Wang,
  • Ibrahim El Tantawy El Sayed,
  • Naser A. Naser,
  • Mohammed Jalal AlAhmed

摘要

Background

Helicobacter pylori (H. pylori) is a common gastrointestinal pathogen that can persist for decades and lead to diseases like gastritis, peptic ulcers, and gastric cancer. Conventional antibiotic treatments have limitations like resistance and side effects, requiring alternative therapies. The gut microbiota may influence H. pylori colonization and eradication success.

Main Body of the abstract

Strategies like probiotics, prebiotics, diet, and lifestyle changes may modulate the gut microbiota composition and function to inhibit H. pylori growth. Specific probiotic strains produce antimicrobial compounds, modulate immune responses, and alter gut microbiota in ways that can promote H. pylori eradication. Diets high in fiber, polyphenols, omega-3s, and fermented foods appear to inhibit H. pylori by supporting growth of beneficial bacteria. Lifestyle factors like stress, smoking, and alcohol negatively impact the gut microbiota. Personalized therapies based on the gut microbiome could optimize eradication rates.

Conclusion

The gut microbiota represents a promising target for enhancing H. pylori eradication. Further research on microbiota-modulating therapies like probiotics, diet, and lifestyle changes may help develop more effective, personalized treatment approaches.