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<p>This experiment investigated the effects of dietary supplementation with GutPlus® Virsorb probiotic on piglets infected with porcine epidemic diarrhea virus (PEDV). Seventy-two Duroc × Landrace × Yorkshire weaned piglets (21&#xa0;days of age, 5.51 ± 0.44&#xa0;kg) were randomly divided into: the CON1 group (negative control, basal diet), the CON2 group (positive control, basal diet), and the GutPlus® Virsorb group (basal diet + 500&#xa0;g/t GutPlus® Virsorb). At 28&#xa0;days of age, piglets in the CON2 and GutPlus® Virsorb groups received 40&#xa0;mL PEDV (8.58 × 10<sup>8</sup> copies/mL) orally, while the CON1 group received an equivalent volume of sterile saline. The experiment lasted until 60&#xa0;days of age. Dietary supplementation with GutPlus® Virsorb ameliorated the decrease in the average daily feed intake (ADFI) and the average daily gain (ADG) caused by PEDV infection. Compared with the CON2 group, GutPlus® Virsorb increased jejunal mucosa GPX and decreased jejunal mucosa MDA. Additionally, GutPlus® Virsorb decreased the mRNA expressions of <i>IFN-β</i>, <i>TNF-α</i>, and <i>IL-6</i> in the jejunal mucosa. Compared to the CON2 group, GutPlus® Virsorb increased relative abundances of <i>Lactobacillus</i>, <i>Prevotella</i>, <i>Akkermansia</i>, and <i>Butyricicoccus_A</i>, while the relative abundance of <i>Clostridium_P</i> and <i>Clostridium_T</i> was reduced. In addition, GutPlus® Virsorb significantly increased the relative quantitative values of cis-cyclo (leucyl-tyrosyl), oxyphenbutazone, callicarpic acid B, and tilisolol. In conclusion, GutPlus® Virsorb improved the growth performance of PEDV-infected piglets, alleviated inflammation and intestinal damage by improving immunity, reduced PEDV copy number, increased antioxidant capacity, and improved gut microbiota structure and metabolite properties, showing a good protective effect against PEDV infection.</p>

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Effects of Bacillus-Based Probiotic Supplementation on Growth Performance, Antioxidant Capacity, Immunity, and Gut Health of PEDV-Infected Piglets

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Benhao Chen,
  • Lixiao Duan,
  • Yan Gao,
  • John kyaw Htoo,
  • S. Maria Mendoza,
  • Kangcheng Pan,
  • Dongmei Zhang,
  • Bo Jing,
  • Yan Zeng,
  • Hongli Ling,
  • Xueqin Ni

摘要

This experiment investigated the effects of dietary supplementation with GutPlus® Virsorb probiotic on piglets infected with porcine epidemic diarrhea virus (PEDV). Seventy-two Duroc × Landrace × Yorkshire weaned piglets (21 days of age, 5.51 ± 0.44 kg) were randomly divided into: the CON1 group (negative control, basal diet), the CON2 group (positive control, basal diet), and the GutPlus® Virsorb group (basal diet + 500 g/t GutPlus® Virsorb). At 28 days of age, piglets in the CON2 and GutPlus® Virsorb groups received 40 mL PEDV (8.58 × 108 copies/mL) orally, while the CON1 group received an equivalent volume of sterile saline. The experiment lasted until 60 days of age. Dietary supplementation with GutPlus® Virsorb ameliorated the decrease in the average daily feed intake (ADFI) and the average daily gain (ADG) caused by PEDV infection. Compared with the CON2 group, GutPlus® Virsorb increased jejunal mucosa GPX and decreased jejunal mucosa MDA. Additionally, GutPlus® Virsorb decreased the mRNA expressions of IFN-β, TNF-α, and IL-6 in the jejunal mucosa. Compared to the CON2 group, GutPlus® Virsorb increased relative abundances of Lactobacillus, Prevotella, Akkermansia, and Butyricicoccus_A, while the relative abundance of Clostridium_P and Clostridium_T was reduced. In addition, GutPlus® Virsorb significantly increased the relative quantitative values of cis-cyclo (leucyl-tyrosyl), oxyphenbutazone, callicarpic acid B, and tilisolol. In conclusion, GutPlus® Virsorb improved the growth performance of PEDV-infected piglets, alleviated inflammation and intestinal damage by improving immunity, reduced PEDV copy number, increased antioxidant capacity, and improved gut microbiota structure and metabolite properties, showing a good protective effect against PEDV infection.