<p>Genital opening or vaginal canal (VC) in women has different embryological origin than the entire female reproductive system. The microenvironment of the VC post puberty is everchanging due to the hormonal fluctuations in a woman’s body. However, the vaginal canal maintains a defined microbiota with higher population of inherent lactic acid bacteria (LAB) species under healthy conditions. The preservation of the beneficial flora in the genital area is dependent on genetic, social, and habitual factors. The understanding and practice of these factors prevents the commencement of various vaginal infections/vaginitis. Common vaginal infections have known antibiotic treatments; however, treatments of few infections are still unavailable. The study of sexual health is scarce in India due to social and economic factors, with less number of studies from various parts of the country. Thus, there is a necessity of new-age prophylactic solutions in such developing countries. This review highlights the origin of the female reproductive system and describes how the hormonal change initiates unique microenvironment development. Later, we have elaborately discussed the precautionary contribution of lactic acid bacteria and their unexplored commercial utilization, which in turn would help in various ways to improve the standards of reproductive hygiene products.</p>