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<p>β-Glucan is a fermentable polysaccharide with prebiotic properties that has been shown to improve metabolic indicators. This study evaluated the effects of spent brewer’s yeast β-glucan (BGL) and <i>Lactobacillus acidophilus</i> LA-5 (10<sup>6</sup>&#xa0;CFU/g) (LA5) alone and in combination (LA5-BGL) on the composition of the fecal microbiome of adults with type 2 diabetes mellitus (T2DM) using the Human Gut Microbial Ecosystem Simulator (SHIME®). Short-chain fatty acids (SCFAs), ammonium ions, and cytokines (IL-6 and IL-10) were measured. BGL, LA5, and LA5-BGL increased (<i>p</i> &lt; <i>0.05</i>) the richness and diversity of microbial communities in the gut microbiome of individuals with T2DM. All treatments increased (<i>p</i> &lt; <i>0.05</i>) the abundance of <i>Bacteroides</i>, <i>Alistipes</i>, <i>Lactobacillus</i>, <i>Subdoligranulum</i>, and <i>Acidaminococcus</i>, along with increased (<i>p</i> &lt; <i>0.05</i>) production of SCFAs and anti-inflammatory cytokine (IL-10) compared to the control group. BGL treatments showed a greater increase in microbial diversity, SCFAs levels (butyric, propionic, and acetic acid), and the anti-inflammatory cytokine (IL-10). LA5 showed the highest decrease in ammonium ion levels. Results indicate that BGL may have a prebiotic and immunomodulatory effect on the fecal microbial community and metabolic indicators in adults with type 2 diabetes mellitus (T2DM). Findings underscore the role of BGL as a prebiotic food.</p>

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β-Glucan Alone or Combined with Lactobacillus acidophilus Positively Influences the Bacterial Diversity and Metabolites in the Colonic Microbiota of Type II Diabetic Patients

  • 期刊论文

  • 发表日期：

    2025年2月26日

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  • Jéssika Rodrigues Clementino,
  • Louise Iara Gomes de Oliveira,
  • Mateus Kawata Salgaço,
  • Fellipe Lopes de Oliveira,
  • Victoria Mesa,
  • Josean Fechine Tavares,
  • Ludmilla Silva-Pereira,
  • Breno Vilas Boas Raimundo,
  • Karen Cristina Oliveira,
  • Alexandra Ivo Medeiros,
  • Francyeli Araújo Silva,
  • Katia Sivieri,
  • Marciane Magnani

摘要

β-Glucan is a fermentable polysaccharide with prebiotic properties that has been shown to improve metabolic indicators. This study evaluated the effects of spent brewer’s yeast β-glucan (BGL) and Lactobacillus acidophilus LA-5 (106 CFU/g) (LA5) alone and in combination (LA5-BGL) on the composition of the fecal microbiome of adults with type 2 diabetes mellitus (T2DM) using the Human Gut Microbial Ecosystem Simulator (SHIME®). Short-chain fatty acids (SCFAs), ammonium ions, and cytokines (IL-6 and IL-10) were measured. BGL, LA5, and LA5-BGL increased (p < 0.05) the richness and diversity of microbial communities in the gut microbiome of individuals with T2DM. All treatments increased (p < 0.05) the abundance of Bacteroides, Alistipes, Lactobacillus, Subdoligranulum, and Acidaminococcus, along with increased (p < 0.05) production of SCFAs and anti-inflammatory cytokine (IL-10) compared to the control group. BGL treatments showed a greater increase in microbial diversity, SCFAs levels (butyric, propionic, and acetic acid), and the anti-inflammatory cytokine (IL-10). LA5 showed the highest decrease in ammonium ion levels. Results indicate that BGL may have a prebiotic and immunomodulatory effect on the fecal microbial community and metabolic indicators in adults with type 2 diabetes mellitus (T2DM). Findings underscore the role of BGL as a prebiotic food.