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<p>Intake of certain <i>Lactiplantibacillus</i> strains was recognized as a potential strategy for acute liver injury (ALI) prevention. This study is aimed at developing a selenium-enriched <i>Lactiplantibacillus</i> strain-based ALI prevention strategy. <i>L. plantarum</i> ZZU 8–12 was isolated from human fecal sample and screened out based on its adaption to intestinal microenvironment, inhibitive capability against pathogenic bacteria, and in vivo anti-inflammation response in DSS-induced colitis mice model. The strain was applied as a producer of nano selenium particles to produce selenium-enriched <i>L. plantarum</i> ZZU 8–12. Intake of selenium-enriched <i>L. plantarum</i> ZZU 8–12 upregulated the abundance of short-chain fatty acid-producing genera including <i>Lactiplantibacillus</i>, <i>Phascolarctobacterium</i>, <i>Butyricicoccus</i>, and <i>Clostridiales bacterium</i> in fecal microbiota and thus inhibited ALI induced by CCL<sub>4</sub> injection in mice. This study drew the potential for selenium-enriched <i>L. plantarum</i> ZZU 8–12 as an ingredient for ALI protection.</p>

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Selenium-Enriched Lactiplantibacillus plantarum ZZU 8–12 Regulates Intestinal Microbiota and Inhibits Acute Liver Injury

  • 期刊论文

  • 发表日期：

    2025年1月28日

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  • Yanping Wang,
  • Hengyu Ma,
  • Haolong Li,
  • Yuhang Huang,
  • Yupeng Tang,
  • Xiaoxue Tang,
  • Pintian Sun,
  • Zhongfang Tan,
  • Huili Pang,
  • Fengyuan Yang

摘要

Intake of certain Lactiplantibacillus strains was recognized as a potential strategy for acute liver injury (ALI) prevention. This study is aimed at developing a selenium-enriched Lactiplantibacillus strain-based ALI prevention strategy. L. plantarum ZZU 8–12 was isolated from human fecal sample and screened out based on its adaption to intestinal microenvironment, inhibitive capability against pathogenic bacteria, and in vivo anti-inflammation response in DSS-induced colitis mice model. The strain was applied as a producer of nano selenium particles to produce selenium-enriched L. plantarum ZZU 8–12. Intake of selenium-enriched L. plantarum ZZU 8–12 upregulated the abundance of short-chain fatty acid-producing genera including Lactiplantibacillus, Phascolarctobacterium, Butyricicoccus, and Clostridiales bacterium in fecal microbiota and thus inhibited ALI induced by CCL4 injection in mice. This study drew the potential for selenium-enriched L. plantarum ZZU 8–12 as an ingredient for ALI protection.